All families / PF22752
PF22752: DUF488-N3i
Inactive DUF488-N3 subclade
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF22752: Inactive DUF488-N3 subclade
IPR052552: integrated entry for Inactive DUF488-N3 subclade
Source description
This entry represents a subclade of DUF488 domains lacking the catalytic residues common to the rhodanese-phosphatase superfamily. The C-terminal core strand is degenerate in this subclade [InterPro reference PUB00153826].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| P65064 | Uncharacterized protein Mb3100c Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) | 118 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P76243 | Uncharacterized protein YeaO Escherichia coli (strain K12) | 115 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P9WL10 | Uncharacterized protein MT3158 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) | 118 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 5,812
- matches
- 5,813
- proteomes
- 5,534
- taxa
- 8,134
- structures
- 0
- alphafold models
- 3,595
- domain architectures
- 19
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF488-N3i (PF22752) | ProteinTraitsMech | Inactive DUF488-N3 subclade | P65064 Uncharacterized protein Mb3100c | canonical example family classification |
| DUF488-N3i (PF22752) | ProteinTraitsMech | Inactive DUF488-N3 subclade | P76243 Uncharacterized protein YeaO | canonical example family classification |
| DUF488-N3i (PF22752) | ProteinTraitsMech | Inactive DUF488-N3 subclade | P9WL10 Uncharacterized protein MT3158 | canonical example family classification |
| DUF488-N3i (PF22752) | ProteinTraitsMech | Inactive DUF488-N3 subclade | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.