DUFMech

All families / PF22989

PF22989: DUF7030

Domain of unknown function (DUF7030)

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF22989: Domain of unknown function (DUF7030)
IPR054294: integrated entry for Domain of unknown function (DUF7030)

Source description

This domain of unknown function is found in Lysine-specific demethylase 3B (KDM3B, also known as JmjC domain-containing histone demethylation protein 2B or JHDM2B) and related proteins. KDM3B is a histone demethylase that specifically demethylates lysine at position 9 of histone H3 [InterPro reference PUB00153916]. This enzyme plays a central role in histone code. This domain is predicted to adopt an open beta-barrel with an SH3-like topology.

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

6 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
Q15652Jumonji domain-containing protein 1C
Homo sapiens
2540 aa; version 2
UniProt 2026_03
UNIPROT FETCH
9 sibling references
Q69ZK6Jumonji domain-containing protein 1C
Mus musculus
2531 aa; version 4
UniProt 2026_03
UNIPROT FETCH
7 sibling references
Q6PCM1Lysine-specific demethylase 3A
Mus musculus
1323 aa; version 1
UniProt 2026_03
UNIPROT FETCH
9 sibling references
Q6ZPY7Lysine-specific demethylase 3B
Mus musculus
1762 aa; version 3
UniProt 2026_03
UNIPROT FETCH
5 sibling references
Q7LBC6Lysine-specific demethylase 3B
Homo sapiens
1761 aa; version 2
UniProt 2026_03
UNIPROT FETCH
6 sibling references
Q9Y4C1Lysine-specific demethylase 3A
Homo sapiens
1321 aa; version 4
UniProt 2026_03
UNIPROT FETCH
8 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
1,996
matches
1,996
proteomes
685
taxa
2,415
structures
0
alphafold models
214
domain architectures
15

Classification basis

short name matches duf; name says unknown function; description says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
DUF7030 (PF22989)ProteinTraitsMechdioxygenase activityQ15652
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechdioxygenase activityQ69ZK6
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechhistone H3K9 demethylase activityQ6PCM1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechhistone H3K9me/H3K9me2 demethylase activityQ6PCM1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechhistone H3K9me/H3K9me2 demethylase activityQ9Y4C1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechprotein demethylase activityQ15652
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechformaldehyde biosynthetic processQ6PCM1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechformaldehyde biosynthetic processQ9Y4C1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechmaintenance of cell numberQ69ZK6
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechplasma cell differentiationQ15652
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechspermatid nucleus elongationQ6PCM1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3A/B-like, DUF7030Q15652
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3A/B-like, DUF7030Q69ZK6
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3A/B-like, DUF7030Q6PCM1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3A/B-like, DUF7030Q6ZPY7
Lysine-specific demethylase 3B
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3A/B-like, DUF7030Q7LBC6
Lysine-specific demethylase 3B
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3A/B-like, DUF7030Q9Y4C1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3A/B-like, DUF7030
trait identifier
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3A/B, tudor domainQ15652
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3A/B, tudor domainQ69ZK6
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3A/B, tudor domainQ6PCM1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3A/B, tudor domainQ6ZPY7
Lysine-specific demethylase 3B
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3A/B, tudor domainQ7LBC6
Lysine-specific demethylase 3B
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3A/B, tudor domainQ9Y4C1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, PWWP domainQ15652
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, PWWP domainQ69ZK6
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, PWWP domainQ6PCM1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, PWWP domainQ6ZPY7
Lysine-specific demethylase 3B
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, PWWP domainQ7LBC6
Lysine-specific demethylase 3B
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, PWWP domainQ9Y4C1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechDomain of unknown function (DUF7030)Q15652
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechDomain of unknown function (DUF7030)Q7LBC6
Lysine-specific demethylase 3B
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechDomain of unknown function (DUF7030)Q9Y4C1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechDomain of unknown function (DUF7030)
trait identifier
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, PWWP domainQ15652
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, PWWP domainQ69ZK6
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, PWWP domainQ6PCM1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, PWWP domainQ6ZPY7
Lysine-specific demethylase 3B
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, PWWP domainQ7LBC6
Lysine-specific demethylase 3B
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, PWWP domainQ9Y4C1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, tudor domainQ15652
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, tudor domainQ69ZK6
Jumonji domain-containing protein 1C
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, tudor domainQ6PCM1
Lysine-specific demethylase 3A
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, tudor domainQ6ZPY7
Lysine-specific demethylase 3B
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, tudor domainQ7LBC6
Lysine-specific demethylase 3B
canonical example family classification
DUF7030 (PF22989)ProteinTraitsMechLysine-specific demethylase 3B, tudor domainQ9Y4C1
Lysine-specific demethylase 3A
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF22989.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.