All families / PF22989
PF22989: DUF7030
Domain of unknown function (DUF7030)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF22989: Domain of unknown function (DUF7030)
IPR054294: integrated entry for Domain of unknown function (DUF7030)
Source description
This domain of unknown function is found in Lysine-specific demethylase 3B (KDM3B, also known as JmjC domain-containing histone demethylation protein 2B or JHDM2B) and related proteins. KDM3B is a histone demethylase that specifically demethylates lysine at position 9 of histone H3 [InterPro reference PUB00153916]. This enzyme plays a central role in histone code. This domain is predicted to adopt an open beta-barrel with an SH3-like topology.
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
6 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q15652 | Jumonji domain-containing protein 1C Homo sapiens | 2540 aa; version 2 UniProt 2026_03 | UNIPROT FETCH9 sibling references |
| Q69ZK6 | Jumonji domain-containing protein 1C Mus musculus | 2531 aa; version 4 UniProt 2026_03 | UNIPROT FETCH |
| Q6PCM1 | Lysine-specific demethylase 3A Mus musculus | 1323 aa; version 1 UniProt 2026_03 | UNIPROT FETCH9 sibling references |
| Q6ZPY7 | Lysine-specific demethylase 3B Mus musculus | 1762 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| Q7LBC6 | Lysine-specific demethylase 3B Homo sapiens | 1761 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q9Y4C1 | Lysine-specific demethylase 3A Homo sapiens | 1321 aa; version 4 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 1,996
- matches
- 1,996
- proteomes
- 685
- taxa
- 2,415
- structures
- 0
- alphafold models
- 214
- domain architectures
- 15
Classification basis
short name matches duf; name says unknown function; description says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF7030 (PF22989) | ProteinTraitsMech | dioxygenase activity | Q15652 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | dioxygenase activity | Q69ZK6 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | histone H3K9 demethylase activity | Q6PCM1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | histone H3K9me/H3K9me2 demethylase activity | Q6PCM1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | histone H3K9me/H3K9me2 demethylase activity | Q9Y4C1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | protein demethylase activity | Q15652 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | formaldehyde biosynthetic process | Q6PCM1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | formaldehyde biosynthetic process | Q9Y4C1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | maintenance of cell number | Q69ZK6 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | plasma cell differentiation | Q15652 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | spermatid nucleus elongation | Q6PCM1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3A/B-like, DUF7030 | Q15652 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3A/B-like, DUF7030 | Q69ZK6 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3A/B-like, DUF7030 | Q6PCM1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3A/B-like, DUF7030 | Q6ZPY7 Lysine-specific demethylase 3B | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3A/B-like, DUF7030 | Q7LBC6 Lysine-specific demethylase 3B | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3A/B-like, DUF7030 | Q9Y4C1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3A/B-like, DUF7030 | trait identifier | |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3A/B, tudor domain | Q15652 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3A/B, tudor domain | Q69ZK6 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3A/B, tudor domain | Q6PCM1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3A/B, tudor domain | Q6ZPY7 Lysine-specific demethylase 3B | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3A/B, tudor domain | Q7LBC6 Lysine-specific demethylase 3B | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3A/B, tudor domain | Q9Y4C1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, PWWP domain | Q15652 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, PWWP domain | Q69ZK6 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, PWWP domain | Q6PCM1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, PWWP domain | Q6ZPY7 Lysine-specific demethylase 3B | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, PWWP domain | Q7LBC6 Lysine-specific demethylase 3B | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, PWWP domain | Q9Y4C1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Domain of unknown function (DUF7030) | Q15652 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Domain of unknown function (DUF7030) | Q7LBC6 Lysine-specific demethylase 3B | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Domain of unknown function (DUF7030) | Q9Y4C1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Domain of unknown function (DUF7030) | trait identifier | |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, PWWP domain | Q15652 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, PWWP domain | Q69ZK6 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, PWWP domain | Q6PCM1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, PWWP domain | Q6ZPY7 Lysine-specific demethylase 3B | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, PWWP domain | Q7LBC6 Lysine-specific demethylase 3B | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, PWWP domain | Q9Y4C1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, tudor domain | Q15652 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, tudor domain | Q69ZK6 Jumonji domain-containing protein 1C | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, tudor domain | Q6PCM1 Lysine-specific demethylase 3A | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, tudor domain | Q6ZPY7 Lysine-specific demethylase 3B | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, tudor domain | Q7LBC6 Lysine-specific demethylase 3B | canonical example family classification |
| DUF7030 (PF22989) | ProteinTraitsMech | Lysine-specific demethylase 3B, tudor domain | Q9Y4C1 Lysine-specific demethylase 3A | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.