All families / PF24663
PF24663: DUF7651
Domain of unknown function (DUF7651)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF24663: Domain of unknown function (DUF7651)
IPR056068: integrated entry for Domain of unknown function (DUF7651)
Source description
This domain is found in the Polycomb group protein EMBRYONIC FLOWER 2 (EMF2) from Arabidopsis thaliana and related proteins. EMF2 is involved in flowering processes by repressing unknown target genes and preventing reproductive development. This domain is predicted to adopt a globular structure that resembles barrel-sandwich hybrid. The beta-sandwich has a topology most similar to C2 domains found in diverse proteins such as CEP120, Dysferlin and Myoferlin.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| Q0JF48 | Polycomb group protein EMF2A Oryza sativa subsp. japonica | 624 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q69KN0 | Polycomb group protein EMF2B Oryza sativa subsp. japonica | 604 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8L6Y4 | Polycomb group protein EMBRYONIC FLOWER 2 Arabidopsis thaliana | 631 aa; version 2 UniProt 2026_03 | UNIPROT FETCH9 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 1,391
- matches
- 1,414
- proteomes
- 363
- taxa
- 1,046
- structures
- 0
- alphafold models
- 1,144
- domain architectures
- 30
Classification basis
short name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF7651 (PF24663) | ProteinTraitsMech | epigenetic programming in the endosperm | Q8L6Y4 Polycomb group protein EMBRYONIC FLOWER 2 | canonical example family classification |
| DUF7651 (PF24663) | ProteinTraitsMech | VEFS-box_EMF2-like | Q8L6Y4 Polycomb group protein EMBRYONIC FLOWER 2 | canonical example family classification |
| DUF7651 (PF24663) | ProteinTraitsMech | ZnB-Zn_EMF2-like | Q8L6Y4 Polycomb group protein EMBRYONIC FLOWER 2 | canonical example family classification |
| DUF7651 (PF24663) | ProteinTraitsMech | EMF2-like, DUF7651 | Q8L6Y4 Polycomb group protein EMBRYONIC FLOWER 2 | canonical example family classification |
| DUF7651 (PF24663) | ProteinTraitsMech | EMF2-like, DUF7651 | trait identifier | |
| DUF7651 (PF24663) | ProteinTraitsMech | Polycomb protein SUZ12-like, zinc finger domain | Q8L6Y4 Polycomb group protein EMBRYONIC FLOWER 2 | canonical example family classification |
| DUF7651 (PF24663) | ProteinTraitsMech | Polycomb protein, VEFS-Box | Q8L6Y4 Polycomb group protein EMBRYONIC FLOWER 2 | canonical example family classification |
| DUF7651 (PF24663) | ProteinTraitsMech | Domain of unknown function (DUF7651) | Q0JF48 Polycomb group protein EMF2A | canonical example family classification |
| DUF7651 (PF24663) | ProteinTraitsMech | Domain of unknown function (DUF7651) | Q69KN0 Polycomb group protein EMF2B | canonical example family classification |
| DUF7651 (PF24663) | ProteinTraitsMech | Domain of unknown function (DUF7651) | Q8L6Y4 Polycomb group protein EMBRYONIC FLOWER 2 | canonical example family classification |
| DUF7651 (PF24663) | ProteinTraitsMech | Domain of unknown function (DUF7651) | trait identifier | |
| DUF7651 (PF24663) | ProteinTraitsMech | Polycomb protein SUZ12-like, Zn domain | Q8L6Y4 Polycomb group protein EMBRYONIC FLOWER 2 | canonical example family classification |
| DUF7651 (PF24663) | ProteinTraitsMech | VEFS-Box of polycomb protein | Q8L6Y4 Polycomb group protein EMBRYONIC FLOWER 2 | canonical example family classification |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.