All families / PF25372
PF25372: LRR_FBXL15
F-box/LRR-repeat protein 15, leucine rich repeat domain
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF25372: F-box/LRR-repeat protein 15, leucine rich repeat domain
IPR057207: integrated entry for F-box/LRR-repeat protein 15, leucine rich repeat domain
Source description
This domain represents a set of tandem leucine rich repeats found in human F-box/LRR-repeat protein 15 (FBXL15) and similar eukaryotic proteins. FBXL15 is the substrate recognition component of a SCF (SKP1-CUL1-F-box protein), an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signalling pathway. It is required for dorsal/ventral pattern formation and bone mass maintenance [InterPro reference PUB00147666].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
22 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A2RT62 | F-box/LRR-repeat protein 16 Mus musculus | 479 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| B8JKV0 | Protein AMN1 homolog Mus musculus | 258 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| P24814 | SCF E3 ubiquitin ligase complex F-box protein GRR1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 1151 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| P34284 | F-box/LRR-repeat protein fbxl-1 Caenorhabditis elegans | 466 aa; version 3 UniProt 2026_03 | UNIPROT FETCH |
| Q5BJ29 | F-box/LRR-repeat protein 7 Mus musculus | 491 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q708Y0 | EIN3-binding F-box protein 2 Arabidopsis thaliana | 623 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8BH16 | F-box/LRR-repeat protein 2 Mus musculus | 423 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
| Q8BID8 | F-box/LRR-repeat protein 14 Mus musculus | 400 aa; version 1 UniProt 2026_03 | UNIPROT FETCH2 sibling references |
| Q8CDU4 | F-box and leucine-rich repeat protein 13 Mus musculus | 790 aa; version 2 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q8IY45 | Protein AMN1 homolog Homo sapiens | 258 aa; version 4 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
First 10 shown; the FASTA and family JSON contain all examples.
4 unresolved candidates
- O49286: PFAM NOT IN CURRENT ENTRY
- Q8BH70: PFAM NOT IN CURRENT ENTRY
- Q9CZV8: PFAM NOT IN CURRENT ENTRY
- Q9LPL4: PFAM NOT IN CURRENT ENTRY
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 30,220
- matches
- 38,539
- proteomes
- 3,479
- taxa
- 9,284
- structures
- 9
- alphafold models
- 24,573
- domain architectures
- 1,075
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.