All families / PF26475
PF26475: DUF8148_C
Domain of unknown function (DUF8148) C-terminal domain
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF26475: Domain of unknown function (DUF8148) C-terminal domain
IPR059016: integrated entry for Domain of unknown function (DUF8148) C-terminal domain
Source description
This entry represents the C-terminal domain from a family of uncharacterised proteins found predominantly in archaea, specifically within the Halobacteria class. The proteins in this family are typically found in species such as Halovenus, Halobellus, and Natrarchaeobaculum, among others. Additionally, some members are associated with viruses like the Pleolipoviridae family. The domain is approximately 60-70 amino acids in length. The proteins containing this domain are predicted to be involved in replication processes, although their exact function remains unknown. The domain is found in proteins that are generally around 600-700 amino acids in length. These proteins are primarily associated with replication functions, as indicated by their presence in replication proteins across various archaeal species and viruses.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
1 verified sequence example. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| C1JJY0 | Uncharacterized protein 1 Halorubrum pleomorphic virus 1 | 500 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 46
- matches
- 46
- proteomes
- 36
- taxa
- 92
- structures
- 0
- alphafold models
- 35
- domain architectures
- 4
Classification basis
name matches duf; name says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF8148_C (PF26475) | ProteinTraitsMech | Domain of unknown function (DUF8148), C-terminal domain | trait identifier | |
| DUF8148_C (PF26475) | ProteinTraitsMech | Domain of unknown function (DUF8148) C-terminal domain | C1JJY0 Uncharacterized protein 1 | canonical example family classification |
| DUF8148_C (PF26475) | ProteinTraitsMech | Domain of unknown function (DUF8148) C-terminal domain | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.