All families / PF26548
PF26548: DUF8179
Putative peptidyl-prolyl cis-trans isomerase domain
- Curation status
- SEEDED
- Seed status
- KNOWN HISTORICAL DUF
- Characterization
- UNSCORED
Grounding
PF26548: Putative peptidyl-prolyl cis-trans isomerase domain
IPR058492: integrated entry for Putative peptidyl-prolyl cis-trans isomerase domain
Source description
This entry represents the C-terminal domain from a family of uncharacterised proteins in Methanobacteriota. The proteins are predominantly found in archaea, specifically within the Methanobacteriota phylum. This includes orders such as Methanobacteriales, Methanosarcinales, and Methanomicrobiales. The proteins in this family are approximately 500 amino acids in length. This domain shows structural similarity to cyclophilin type peptidyl-prolyl cis-trans isomerases. Domains 2 and 3 in these proteins also adopt the same fold.
Evidence and references
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| A6UVQ1 | UPF0288 protein Maeo_0995 Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) | 501 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q58807 | UPF0288 protein MJ1412 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) | 498 aa; version 2 UniProt 2026_03 | UNIPROT FETCH |
| Q8TX79 | UPF0288 protein MK0796 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) | 511 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 162
- matches
- 162
- proteomes
- 159
- taxa
- 304
- structures
- 3
- alphafold models
- 142
- domain architectures
- 2
Classification basis
short name matches duf
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF8179 (PF26548) | ProteinTraitsMech | methyl-coenzyme M reductase-associated protein Mmp3 | Q58807 UPF0288 protein MJ1412 | canonical example family classification |
| DUF8179 (PF26548) | ProteinTraitsMech | UPF0288-like, C-terminal domain | Q58807 UPF0288 protein MJ1412 | canonical example family classification |
| DUF8179 (PF26548) | ProteinTraitsMech | UPF0288-like, C-terminal domain | trait identifier | |
| DUF8179 (PF26548) | ProteinTraitsMech | Putative peptidyl-prolyl cis-trans isomerase domain | A6UVQ1 UPF0288 protein Maeo_0995 | canonical example family classification |
| DUF8179 (PF26548) | ProteinTraitsMech | Putative peptidyl-prolyl cis-trans isomerase domain | Q58807 UPF0288 protein MJ1412 | canonical example family classification |
| DUF8179 (PF26548) | ProteinTraitsMech | Putative peptidyl-prolyl cis-trans isomerase domain | Q8TX79 UPF0288 protein MK0796 | canonical example family classification |
| DUF8179 (PF26548) | ProteinTraitsMech | Putative peptidyl-prolyl cis-trans isomerase domain | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.