All families / PF26607
PF26607: Beta-prop_PLL
PLL-like beta propeller
- Curation status
- SEEDED
- Seed status
- EX DUF
- Characterization
- UNSCORED
Grounding
PF26607: PLL-like beta propeller
IPR058502: integrated entry for PLL-like beta propeller
Source description
This domain, previously known as DUF8189, is found in the L-fucose-binding lectins PHL and PLLs(1-5) from various Photorhabdus species and their homologues. This domain forms a seven-bladed beta-propeller [InterPro reference PUB00100843,InterPro reference PUB00109482,InterPro reference PUB00161611]. Each blade makes a W-motif composed of four antiparallel beta-strands (beta1-beta4) connected by beta-turns and loops. The C and N terminus are located on the same side of the torus and create a cap of the inner cavity of the torus. With exception of PLL3, which is a monomer, all other domains assemble into oligomeric structures, either homo-dimeric or homo-tetrameric, connected with an inter-subunit disulfide bridge [InterPro reference PUB00100843,InterPro reference PUB00109482,InterPro reference PUB00161611]. Besides L-fucose or fucosylated saccharides, some of these domains bind to unusual O-methylated disaccharide 3,6-O-Me2-d-Glc-beta1-4(2,3-O-Me2)-l-Rha-alpha (MGMR) [InterPro reference PUB00161611].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
No sibling protein candidate in the scanned commits.
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 3,295
- matches
- 3,660
- proteomes
- 1,819
- taxa
- 3,095
- structures
- 31
- alphafold models
- 1,884
- domain architectures
- 208
Classification basis
pfam previous unknown name
No scoring reasons supplied.
Related Mech records
This family joined the worklist after the frozen cross-Mech scan, so other Mechs were not searched for it. Missing links here are not evidence that other Mechs lack it; rows shown come from mentions of a former DUF/UPF name.
No cross-Mech examples are present in the supplied snapshot.
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.