lasalocid

CHEBI:92181 EXACT SEEDED antiparasitic

What these status tags mean

Curation status describes a workflow state. SEEDED means the record entered through the source-seeding workflow; it does not imply that no later curation occurred. PROPOSED marks an addition awaiting review; REVIEWED records curator sign-off on identity, structure, filing class and producer claims; DEPRECATED retains a superseded or out-of-scope record. These are workflow decisions, not independently verified human review. Agent-assisted contributions may appear in the record history.

Grounding describes the identifier mapping: EXACT uses an ontology identity asserted by the source; MINTED keeps a local identifier when no defensible ontology identity is available; REVIEW_NEEDED flags an exact structure whose ontology identity needs adjudication. The grounding note retains any unresolved alternatives. These tags do not establish the strength of producer or activity evidence.

A polyether antibiotic used for prevention and treatment of coccidiosis in poultry.

Structure

Standard InChIKey	BBMULGJBVDDDNI-OWKLGTHSSA-N
SMILES	[H][C@@](C)(CCC1=C(C(O)=O)C(O)=C(C)C=C1)[C@]([H])(O)[C@]([H])(C)C(=O)[C@]([H])(CC)[C@@]1([H])O[C@@](CC)(C[C@@H]1C)[C@@]1([H])CC[C@](O)(CC)[C@H](C)O1
Stereochemistry	fully defined

Filing pathway

Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.

Producer organisms 1

A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.

Taxon	Basis	Cluster	Evidence
Streptomyces sp. Strain: FXJ1.172 NCBITaxon:1931	SOURCE_ASSERTION	mibig:BGC0001648	DOI:10.1128/AEM.02915-10, DOI:10.1271/bbb.80631, https://www.ncbi.nlm.nih.gov/nuccore/KT591188.1 reference DOI:10.1128/AEM.02915-10 evidence type DATABASE_ASSERTION notes MIBiG BGC0001648 entry version 5; claim-specific citation selected through a reviewed producer_reference correction. This remains a database assertion, not independently graded experimental evidence. reference DOI:10.1271/bbb.80631 evidence type CURATOR_INFERENCE notes Citation routing only. The imported PMID:19129623 studies ATCC35851/pKSL/AB449340, not FXJ1.172/KT591188.1. The inspected 2011 producer study identifies FXJ1.172 product as lasalocid A by mass, UV and MS2 comparison to JCM3373; it does not independently determine absolute stereochemistry or characterize the entire deposited cluster. Route the locus claim to KT591188.1, a putative partial BGC submission, not to the AB449340 experiment. Preserve source-tier grades and original raw references; no taxon, chemistry or locus-coordinate change. See issue #972. Original imported citation PMID:19129623 (ENTRY) remains in the raw inventory, not as support for this claim. MIBiG source row BGC0001648:1; SHA256 fbb9c924907a87713a15ff6323080124a5dea60a58dead6a941dcf34b7c83b58. Curator: codex; date: 2026-10-14. Taxon, locus, chemistry and evidence grades are unchanged. reference https://www.ncbi.nlm.nih.gov/nuccore/KT591188.1 evidence type CURATOR_INFERENCE notes Strain context: FXJ1.172. KT591188.1 names strain FXJ1.172, also identified as a lasalocid A producer in DOI:10.1128/AEM.02915-10. Preserve deposited NCBITaxon:1931; adding this qualifier does not remap to NCBITaxon:710705, certify absolute stereochemistry or upgrade producer/locus evidence grades. See issue #973. Taxon identity and evidence grade are unchanged; this is not a species-wide experiment. MIBiG source row BGC0001648:1; SHA256 fbb9c924907a87713a15ff6323080124a5dea60a58dead6a941dcf34b7c83b58. Curator: codex; date: 2026-10-14.

Occurrences 3

Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.

Taxon	Source	Reference
Streptomyces NCBITaxon:1883	LOTUS	DOI:10.1039/C29700000071
Streptomyces NCBITaxon:1883	LOTUS	DOI:10.1271/BBB.80631
Streptomyces lasalocidi NCBITaxon:324833	CHEBI	PMID:32228806

Biosynthetic gene clusters 1

Accession	Host	Locus evidence	Genome
mibig:BGC0001648	Streptomyces sp. NCBITaxon:1931	CLUSTER_UNSTATED	genbank:KT591188.1

A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.

Mechanism & Biosynthesis Overview

Elsewhere in the fleet

AntibioticMech — CHEBI:92181 (same structure, same inchikey)

Explore across X-Mech

AntibioticMech (lasalocid) ↗ MediaIngredientMech (CHEBI:92181) ↗ TaxonMech: Streptomyces sp. (NCBITaxon:1931) ↗ PathwayMech (mibig:BGC0001648) ↗

Provenance

Source concept	Source	Version
BGC0001648	MIBIG	5
CHEBI:92181	CHEBI	3-star

This page is generated from data/natural_products/polyketides/lasalocid.yaml, which is generated from the committed inventories. Neither is edited by hand.