methymycin
CHEBI:29630 EXACT SEEDED antibacterial
A twelve-membered macrolide antibiotic that is biosynthesised by Streptomyces venezuelae.
Structure
| Standard InChIKey | HUKYPYXOBINMND-HYUJHOPRSA-N |
|---|---|
| SMILES | CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@H](C)C[C@@H](C)C(=O)\C=C\[C@]1(C)O |
| Stereochemistry | fully defined |
| Cross-references | npatlas:NPA01238, pubchem:5282034 |
Filing pathway
Polyketides — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, saccharide, from MIBiG.
Producer organisms 2
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces venezuelae NCBITaxon:54571 |
SOURCE_ASSERTION | mibig:BGC0000094 | PMID:9770448 |
| Streptomyces venezuelae NCBITaxon:54571 |
SOURCE_ASSERTION | mibig:BGC0000898 | PMID:9770448 |
Occurrences 19
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1021/JA01605A026 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1002/PRO.2204 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1007/S00253-008-1455-9 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1007/S10295-018-2024-6 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1007/S12272-012-0907-Z |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1016/J.JBIOTEC.2015.12.028 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1016/S0378-1119(00)00560-6 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1016/S0960-894X(98)00553-8 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1016/S1074-5521(98)90293-9 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1021/JA00055A023 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1021/JA974321V |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1021/JA981500J |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1021/JA981782N |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1021/NP010146R |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1073/PNAS.95.21.12111 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1074/JBC.M605478200 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.1128/GENOMEA.00337-16 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.7164/ANTIBIOTICS.30.76 |
| Streptomyces venezuelae NCBITaxon:54571 |
LOTUS | DOI:10.7164/ANTIBIOTICS.45.1981 |
Biosynthetic gene clusters 2
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000094 | Streptomyces venezuelae NCBITaxon:54571 |
CLUSTER_DEMONSTRATED | genbank:AF079138.1 |
| mibig:BGC0000898 | Streptomyces venezuelae NCBITaxon:54571 |
CLUSTER_UNSTATED | genbank:AF079762.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:29630 (same structure, same inchikey)
Open questions 2
name-disagreement — ChEBI calls this structure 'methymycin' and MIBiG calls it 'desosamine'. They share a Standard InChIKey, so if the names denote different compounds then one upstream record has the wrong structure. Check which.
shared-structure — This structure is reported by more than one MIBiG entry: BGC0000094, BGC0000898. Confirm they describe the same compound rather than an upstream cross-reference error.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000094 | MIBIG | 5 |
| BGC0000898 | MIBIG | 5 |
| CHEBI:29630 | CHEBI | 3-star |
This page is generated from data/natural_products/polyketides/methymycin.yaml, which is generated from the committed inventories. Neither is edited by hand.