clorobiocin
naturalproductmech:mibig-619480541f MINTED SEEDED antibacterialenzyme inhibitor
Structure
| Standard InChIKey | FJAQNRBDVKIIKK-LFLQOBSNSA-N |
|---|---|
| SMILES | CC1=CC=C(N1)C(=O)O[C@H]2[C@H]([C@@H](OC([C@@H]2OC)(C)C)OC3=C(C4=C(C=C3)C(=C(C(=O)O4)NC(=O)C5=CC(=C(C=C5)O)CC=C(C)C)O)Cl)O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:54706138 |
Filing pathway
Shikimates and phenylpropanoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is saccharide, other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces roseochromogenus subsp. oscitans DS 12.976 NCBITaxon:1352936 |
BGC_CHARACTERIZED | mibig:BGC0000832 | PMID:12480894 |
Occurrences 1
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.1002/CHIN.197249433 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000832 | Streptomyces roseochromogenus subsp. oscitans DS 12.976 NCBITaxon:1352936 |
CLUSTER_DEMONSTRATED | genbank:AF329398.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Bioactivities 2
| Assay | Result | Reference |
|---|---|---|
| Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB | KD 0.0012 uM | PMID:12044152 |
| Experimentally measured binding affinity data derived from PDB | ACTIVE | PMID:12044152 |
Elsewhere in the fleet
- AntibioticMech — antibioticmech:aro-e44e701df2 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000832 | MIBIG | 4 |
This page is generated from data/natural_products/shikimates_and_phenylpropanoids/clorobiocin.yaml, which is generated from the committed inventories. Neither is edited by hand.