pactamycin
naturalproductmech:mibig-608a44baf3 MINTED SEEDED antibacterial
Structure
| Standard InChIKey | WVIUOSJLUCTGFK-JUJPXXQGSA-N |
|---|---|
| SMILES | CC1=C(C(=CC=C1)O)C(=O)OC[C@]2([C@H]([C@@H]([C@]([C@@]2(C)O)([C@H](C)O)NC(=O)N(C)C)N)NC3=CC=CC(=C3)C(=O)C)O |
| Stereochemistry | fully defined |
| Cross-references | pubchem:5289124 |
Filing pathway
Terpenoids — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is pks, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces pactum NCBITaxon:68249 |
SOURCE_ASSERTION | mibig:BGC0000118 | PMID:17827660 |
Occurrences 9
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces NCBITaxon:1883 |
LOTUS | DOI:10.7164/ANTIBIOTICS.39.1779 |
| Streptomyces pactum NCBITaxon:68249 |
LOTUS | DOI:10.1007/S00253-018-9375-9 |
| Streptomyces pactum NCBITaxon:68249 |
LOTUS | DOI:10.1016/0378-1119(90)90140-M |
| Streptomyces pactum NCBITaxon:68249 |
LOTUS | DOI:10.1021/JA00398A042 |
| Streptomyces pactum NCBITaxon:68249 |
LOTUS | DOI:10.1021/JO00830A035 |
| Streptomyces pactum NCBITaxon:68249 |
LOTUS | DOI:10.1099/00221287-135-5-1071 |
| Streptomyces pactum NCBITaxon:68249 |
LOTUS | DOI:10.1128/AM.10.4.302-304.1962 |
| Streptomyces pactum NCBITaxon:68249 |
LOTUS | DOI:10.1128/JB.173.22.7213-7218.1991 |
| Streptomyces pactum NCBITaxon:68249 |
LOTUS | DOI:10.7164/ANTIBIOTICS.47.1456 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0000118 | Streptomyces pactum NCBITaxon:68249 |
CLUSTER_UNSTATED | genbank:AB303063.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — antibioticmech:aro-8218cfc5a1 (same structure, same inchikey)
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0000118 | MIBIG | 5 |
This page is generated from data/natural_products/terpenoids/pactamycin.yaml, which is generated from the committed inventories. Neither is edited by hand.