bicozamycin
CHEBI:60584 EXACT SEEDED antibacterial
A commercially important azabicyclic antibiotic obtained from Streptomyces sapporonensis. It inhibits the Rho protein of E. coli.
Structure
| Standard InChIKey | WOUDXEYYJPOSNE-VKZDFBPFSA-N |
|---|---|
| SMILES | [H][C@](O)([C@@](C)(O)CO)[C@@]12NC(=O)[C@@](O)(NC1=O)C(=C)CCO2 |
| Stereochemistry | fully defined |
| Cross-references | pubchem:70685091, npatlas:NPA09159 |
Filing pathway
Unclassified — computed by NPClassifier npclassifier.gnps2.org@2026-09-07, which is why it is pinned rather than recomputed. The gene cluster's asserted class is other, from MIBiG.
Producer organisms 1
A claim that this taxon makes the compound. The basis says what the evidence addressed — a knockout and a database assertion are not the same claim.
| Taxon | Basis | Cluster | Evidence |
|---|---|---|---|
| Streptomyces cinnamoneus NCBITaxon:53446 |
SOURCE_ASSERTION | mibig:BGC0001468 | PMID:8466900 |
Occurrences 6
Somebody found the compound in this organism and cited it. That is not a claim that the organism makes it, and nothing here promotes one to the other.
| Taxon | Source | Reference |
|---|---|---|
| Streptomyces griseoflavus NCBITaxon:35619 |
LOTUS | DOI:10.1099/00221287-130-8-2007 |
| Streptomyces griseoflavus NCBITaxon:35619 |
LOTUS | DOI:10.7164/ANTIBIOTICS.41.1106 |
| Streptomyces sapporonensis NCBITaxon:97401 |
LOTUS | DOI:10.1016/0040-4039(96)01521-3 |
| Streptomyces sapporonensis NCBITaxon:97401 |
LOTUS | DOI:10.1038/S41598-019-56747-7 |
| Streptomyces cinnamoneus NCBITaxon:53446 |
LOTUS | DOI:10.1016/0040-4039(96)01521-3 |
| Streptomyces cinnamoneus NCBITaxon:53446 |
LOTUS | DOI:10.1038/S41598-019-56747-7 |
Biosynthetic gene clusters 1
| Accession | Host | Locus evidence | Genome |
|---|---|---|---|
| mibig:BGC0001468 | Streptomyces cinnamoneus NCBITaxon:53446 |
CLUSTER_DEMONSTRATED | genbank:PKFQ01000001.1 |
A locus claim and a taxon claim are different questions. Heterologous expression settles the first and leaves the second where the isolation report left it.
Elsewhere in the fleet
- AntibioticMech — CHEBI:60584 (same structure, same inchikey)
Open questions 1
name-disagreement — ChEBI calls this structure 'bicozamycin' and MIBiG calls it 'bicyclomycin'. They share a Standard InChIKey, so if the names denote different compounds then one upstream record has the wrong structure. Check which.
Provenance
| Source concept | Source | Version |
|---|---|---|
| BGC0001468 | MIBIG | 5 |
| CHEBI:60584 | CHEBI | 3-star |
This page is generated from data/natural_products/unclassified/bicozamycin.yaml, which is generated from the committed inventories. Neither is edited by hand.