enzyme
METPO:1000527 · CLASS · REVIEWED
A biological macromolecule (typically a protein, occasionally a catalytic RNA) that catalyses a specific biochemical reaction. This class is the material-entity sense of "enzyme" (the molecule itself), matching METPO:1000527's placement as a subclass of METPO:1000186 (material entity). Used as the range class for METPO enzyme-related OBJECT_PROPERTYs (shows_activity_of, enzyme_activity_analyzed, does_not_show_activity_of).
Provenance
- Source
- METPO (2025-11-25)
- Definition source
- DOI:10.1093/nar/gku1003
Parent traits (1)
kg-microbe context
Matched 1 kg-microbe node via direct_metpo.
METPO:1000527[+0.167, -0.909, -0.249, +1.095, …]
Nearest neighbors in embedding space
- upper microbe 0.969
- upper chemical entity 0.957
- upper material entity 0.950
- metabolism organism interacts with chemical 0.376
- metabolism has quality 0.370
- metabolism has phenotype 0.368
- metabolism does not transport 0.364
- metabolism transports 0.364
Curation history
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CREATED_UPPER_CLASS_RECORD · claude
Created upper-ontology CLASS record for METPO:1000527 (enzyme) so that the range of un-deprecated activity-assay OBJECT_PROPERTYs (shows_activity_of, enzyme_activity_analyzed, and their negation companions) resolves to a curated TraitMech record.
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REMOVED_NON_EQUIVALENT_XREFS_AND_TIGHTENED_DEFINITION · claude
Per Copilot review of PR #55, removed xrefs to GO:0003824 (catalytic activity) and CHEBI:23357 (catalyst). Neither is an equivalence mapping: GO:0003824 is an activity/process class and CHEBI:23357 is a role, while this record represents the enzyme material entity. The definition was rewritten to be strictly about the enzyme molecule itself, removing the earlier wording that conflated material entity with catalytic activity. No clean cross-ontology equivalent for the material-entity "enzyme" class is available (CHEBI does not have a single enzyme class; PR is too broad as "protein"), so xrefs is left empty.