ventral disc crossbridge

GO:0097595 · Cytoskeleton · Other · Proposed

A fibrous structure that horizontally links adjacent dorsal microribbons in the ventral disc of Giardia species trophozoites. [GO:0097595]

Part of: ventral disc (GO:0097597)

Taxonomic distribution

NCBITaxon:5741 Giardia intestinalis — COMMON: Giardia intestinalis is the diplomonad species in which ventral-disc crossbridges were mapped between adjacent dorsal microribbons. [DOI:10.1371/journal.pone.0043783]

NCBITaxon:5741 Giardia intestinalis — Parasitic diplomonad model used for electron-tomographic mapping of crossbridges in the ventral-disc microribbon lattice. [DOI:10.1371/journal.pone.0043783]

ventral disc microribbon lattice linkage — Crossbridges link neighboring Giardia ventral-disc dorsal microribbons into the lateral microribbon lattice above the microtubule spiral.
- GO:0097595 Gene Ontology defines ventral-disc crossbridges as horizontal links between adjacent microribbons.
- DOI:10.1371/journal.pone.0043783 Schwartz et al. 2012 describe the crossbridges linking neighboring dorsal microribbons in the Giardia ventral disc.

In Giardia, ventral-disc crossbridges link adjacent dorsal microribbons within the ventral disc.

Subject	Predicate	Object	Evidence
ventral disc crossbridge	links	ventral disc dorsal microribbon	`GO:0097595` Gene Ontology defines ventral-disc crossbridges as horizontal links between adjacent microribbons. `DOI:10.1371/journal.pone.0043783` Schwartz et al. 2012 mapped crossbridges between neighboring microribbons by cryo-electron tomography.
ventral disc crossbridge	is part of	ventral disc	`GO:0097595` Gene Ontology models GO:0097595 as part of GO:0097597, the ventral disc.

CURATION_TODO (OPEN): Resolve exact source-neutral groundings and finer component boundaries for Giardia ventral-disc crossbridge proteins. This first ventral-disc crossbridge record keeps exact crossbridge composition unresolved because GO and Schwartz et al. establish the crossbridge as a fibrous ventral-disc structure, but this pass did not verify its protein constituents, stable component boundaries or source-neutral family CURIEs.

GO:0097595 Gene Ontology cellular-component term for the Giardia ventral-disc crossbridge.
DOI:10.1371/journal.pone.0043783 Schwartz, Heumann, Dawson and Hoenger 2012, 'A Detailed, Hierarchical Study of Giardia lamblia's Ventral Disc Reveals Novel Microtubule-Associated Protein Complexes', PLOS ONE.

2026-09-15T15:38:44Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-15T15:39:20Z codex · EXPANDED_RECORD — Added ventral-disc partonomy, label-only crossbridge structural proteins, Giardia intestinalis scope, DOI evidence, a nonmechanistic crossbridge assembly graph, and a crossbridge-protein grounding TODO.
2026-09-15T15:49:51Z codex · REVIEW_FIX — Addressed PR #993 review issue #995 by removing the unsupported label-only crossbridge structural-protein component and retargeting the exact-composition TODO to the crossbridge graph.