ventral disc lateral crest

GO:0097591 · Cytoskeleton · Other · Proposed

A fibrillar repetitive structure that surrounds the edge of the ventral disc in Giardia species trophozoites. [GO:0097591]

Part of: ventral disc (GO:0097597)

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
ventral disc lateral-crest structural proteins	Protein	part of	Reviewed label only (reviewed name; no accession asserted)			UNKNOWN	Giardia cytoskeletal proteins that localize to the lateral crest and contribute to the fibrillar repetitive edge of the ventral disc. `DOI:10.1371/journal.pntd.0001442` Hagen et al. 2011 identified novel Giardia proteins that localize to the ventral-disc lateral crest.

NCBITaxon:5741 Giardia intestinalis — COMMON: Giardia intestinalis is the diplomonad species in which lateral crest proteins were localized at the ventral-disc edge. [DOI:10.1371/journal.pntd.0001442]

NCBITaxon:5741 Giardia intestinalis — Parasitic diplomonad model used for fluorescence localization of lateral-crest proteins around the ventral-disc edge. [DOI:10.1371/journal.pntd.0001442]

ventral disc edge scaffold — The lateral crest forms the fibrillar repetitive edge that surrounds the Giardia ventral disc.
- GO:0097591 Gene Ontology models the lateral crest as a fibrillar repetitive structure surrounding the ventral-disc edge.
- DOI:10.1371/journal.pntd.0001442 Hagen et al. 2011 localized lateral-crest proteins at the Giardia ventral-disc margin.

In Giardia, the lateral crest is the fibrillar structure that surrounds the edge of the ventral disc.

Subject	Predicate	Object	Evidence
ventral disc lateral crest	surrounds	ventral disc	`GO:0097591` Gene Ontology defines the lateral crest as surrounding the ventral-disc edge.
ventral disc lateral crest	is part of	ventral disc	`GO:0097591` Gene Ontology models GO:0097591 as part of GO:0097597, the ventral disc.

CURATION_TODO (OPEN): Resolve exact source-neutral groundings and finer component boundaries for Giardia ventral-disc lateral-crest proteins. This first ventral-disc lateral-crest record keeps a broad reviewed label-only lateral-crest protein cohort because Hagen et al. localized proteins to the lateral crest, but this pass did not verify exact source-neutral protein-family CURIEs or stable subcomplex boundaries.

GO:0097591 Gene Ontology cellular-component term for the Giardia ventral-disc lateral crest.
DOI:10.1371/journal.pntd.0001442 Hagen, Schwartz, Carlton and Dawson 2011, 'Novel Structural Components of the Ventral Disc and Lateral Crest in Giardia intestinalis', PLOS Neglected Tropical Diseases.

2026-09-15T16:07:03Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-15T16:07:39Z codex · EXPANDED_RECORD — Added ventral-disc partonomy, a label-only lateral-crest structural protein component, Giardia intestinalis scope, DOI evidence, a nonmechanistic lateral-crest edge graph, and a lateral-crest protein grounding TODO.
2026-09-15T16:17:18Z codex · REVIEW_FIX — Addressed PR #996 review issue #997 by removing the lateral-crest protein localization observation from the graph and retargeting the graph to the GO-backed lateral-crest edge relation.