ventral disc overlap zone

GO:0097592 · Cytoskeleton · Other · Proposed

A region of the ventral disc of Giardia species (trophozoite stage) where two portions of the same array of microtubules overlap (the microtubule array makes a complete circle and overlaps on itself). [GO:0097592]

Synonyms: overlap zone; ventral disk overlap zone

Part of: ventral disc (GO:0097597)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Taxonomic distribution

NCBITaxon:5741 Giardia intestinalis — COMMON: Giardia intestinalis is the diplomonad species in which the ventral-disc microtubule spiral and overlap-region geometry were mapped by electron tomography. [DOI:10.1371/journal.pone.0043783]

Canonical examples

NCBITaxon:5741 Giardia intestinalis — Parasitic diplomonad model used for electron-tomographic mapping of ventral-disc microtubule organization. [DOI:10.1371/journal.pone.0043783]

Mechanism graphs

Giardia overlap zone marks ventral-disc microtubule self-overlap (FUNCTION)

In Giardia, the ventral disc overlap zone is the region where two portions of the same microtubule array overlap after the spiral makes a complete circle.

Subject	Predicate	Object	Evidence
ventral disc overlap zone	marks self-overlap of	ventral disc microtubule array	`GO:0097592` Gene Ontology defines GO:0097592 by the self-overlap of the ventral-disc microtubule array.
ventral disc overlap zone	is part of	ventral disc	`GO:0097592` Gene Ontology defines the overlap zone as a region of the ventral disc.

Discussions

CURATION_TODO (OPEN): Resolve exact microtubule-segment boundaries and any accessory structures specific to the Giardia ventral-disc overlap zone. This first overlap-zone record keeps the GO:0097592 entity at the topology layer because the zone is the region where two portions of the same ventral-disc microtubule array overlap; exact segment boundaries and any local accessory densities were not verified in this pass.

Evidence

GO:0097592 Gene Ontology cellular-component term for the Giardia ventral-disc overlap zone.
DOI:10.1371/journal.pone.0043783 Schwartz, Heumann, Dawson and Hoenger 2012, 'A Detailed, Hierarchical Study of Giardia lamblia's Ventral Disc Reveals Novel Microtubule-Associated Protein Complexes', PLOS ONE.

Curation history

2026-09-15T16:58:00Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-15T16:58:31Z codex · EXPANDED_RECORD — Added GO overlap-zone synonyms, ventral-disc partonomy, a label-only tubulin component, Giardia intestinalis scope, DOI evidence, a nonmechanistic overlap-zone topology graph, and an overlap-zone component-boundary TODO.
2026-09-15T17:09:42Z codex · REVIEW_FIX — Addressed PR #1002 review issue #1003 by removing duplicate generic microtubule and tubulin composition from the spatial overlap-zone record, then retargeting the TODO to overlap-zone boundary curation.

Source: data/structures/cytoskeleton/ventral_disc_overlap_zone.yaml