eisosome membrane domain/MCC

GO:0090512 · Envelope · Subcellular region · Proposed

A plasma membrane part that is composed of a furrow-like plasma membrane domain and associated integral transmembrane proteins. [GO:0090512]

Synonyms: membrane compartment of Can1; MCC

Part of: eisosome (GO:0032126)

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
Sur7 MCC integral membrane protein	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SUR7			Integral plasma-membrane protein that marks the MCC membrane domain paired with the eisosome filament. `DOI:10.1038/nature04472` Walther et al. 2006 identified Saccharomyces cerevisiae Sur7 as a plasma-membrane protein localized to eisosomes. `PMID:25002088` Douglas and Konopka 2014 reviewed Sur7 as an integral protein of fungal MCC/eisosome domains.

NCBITaxon:4751 Fungi — VARIABLE: MCC/eisosome membrane domains have been described in fungi, but the component set and domain architecture vary by lineage. [PMID:25002088]
NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast carries Sur7-marked furrow-like MCC plasma-membrane domains paired with eisosome filaments. [DOI:10.1038/nature04472]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which the plasma-membrane protein Sur7 was localized to eisosome-associated membrane domains. [DOI:10.1038/nature04472]

stable plasma-membrane compartmentation — The MCC membrane domain forms a stable furrow-like plasma-membrane compartment that organizes integral membrane proteins in fungal eisosomes.
- PMID:25002088 Douglas and Konopka 2014 reviewed MCC/eisosomes as stable fungal plasma-membrane domains.
- DOI:10.1083/jcb.201104040 Karotki et al. 2011 connected Pil1/Lsp1 filament assembly to MCC/eisosome membrane scaffolding.

Sur7 localizes in the MCC membrane domain, while adjacent Pil1/Lsp1 eisosome filaments scaffold that furrow-like plasma-membrane domain.

Subject	Predicate	Object	Evidence
Sur7 MCC integral membrane protein	localizes to	eisosome membrane domain/MCC	`DOI:10.1038/nature04472` Walther et al. 2006 found that Sur7 localizes to immobile plasma-membrane eisosome domains.
eisosome filament	scaffolds	eisosome membrane domain/MCC	`DOI:10.1083/jcb.201104040` Karotki et al. 2011 showed that purified Pil1 and Lsp1 assemble into eisosome-like membrane scaffolds.

CURATION_TODO (OPEN): Resolve exact family groundings for Sur7, Nce102, and other integral membrane proteins of MCC/eisosome domains. Sur7 is an experimentally established marker of the MCC membrane domain, but no exact source-neutral family CURIE for Sur7-family membrane proteins was curated in this pass. Additional MCC/eisosome residents should be added only after their component boundaries and exact family groundings are resolved.

GO:0090512 Gene Ontology cellular-component term for eisosome membrane domain/MCC.
GO:0044853 Gene Ontology cellular-component parent term for plasma membrane raft.
GO:0032126 Gene Ontology cellular-component term for eisosome.
GO:0036286 Gene Ontology cellular-component term for the paired eisosome filament.
DOI:10.1038/nature04472 Walther et al. 2006, Eisosomes mark static sites of endocytosis, Nature.
DOI:10.1083/jcb.201104040 Karotki et al. 2011, Eisosome proteins assemble into a membrane scaffold, Journal of Cell Biology.
PMID:25002088 Douglas and Konopka 2014, Fungal membrane organization: the eisosome concept, Annual Review of Microbiology.

2026-09-15T23:21:43Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-15T23:22:19Z codex · EXPANDED_RECORD — Added plasma-membrane-raft parentage, eisosome parthood, Sur7-family MCC integral membrane proteins with reviewed label-only grounding, fungal and Saccharomyces cerevisiae scope, MCC compartmentation evidence, an eisosome-filament scaffolding graph, and a membrane-protein grounding TODO.
2026-09-15T23:35:47Z codex · ADDRESS_REVIEW — Resolved #1039 by narrowing the unresolved Sur7-family MCC membrane component to the demonstrated Sur7 marker.
2026-09-21T12:05:18Z codex · REPLACED_UNREADABLE_EVIDENCE — Resolved #1239 by routing Douglas and Konopka 2014 fungal MCC/eisosome evidence through reachable PMID:25002088 instead of the unreadable Annual Reviews DOI.