eisosome

GO:0032126 · Other · Subcellular region · Proposed

A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization. [GO:0032126]

Synonyms: MCC/eisosome

Has part: eisosome filament (GO:0036286); eisosome membrane domain/MCC (GO:0090512)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
Pil1/Lsp1 BAR-domain eisosome core	Protein	part of	`InterPro:IPR028245`	PIL1, LSP1			Fungal BAR-domain proteins that form the cytoplasmic eisosome filament scaffold. `DOI:10.1091/mbc.e10-12-1021` Olivera-Couto et al. 2011 identified Pil1 and Lsp1 as the BAR-domain core components of Saccharomyces cerevisiae eisosomes. `DOI:10.1083/jcb.201104040` Karotki et al. 2011 reconstituted purified yeast Pil1 and Lsp1 into filaments and membrane-associated scaffolds.
Sur7 MCC integral membrane protein	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SUR7			An integral plasma-membrane protein that localizes to the membrane-compartment-of-Can1 domain within eisosomes. `DOI:10.1038/nature04472` Walther et al. 2006 identified the plasma-membrane protein Sur7 as an eisosome-localized protein. `PMID:25002088` Douglas and Konopka 2014 reviewed Sur7-family proteins as integral proteins of fungal MCC/eisosome domains.

Taxonomic distribution

NCBITaxon:4751 Fungi — VARIABLE: MCC/eisosome domains have been described across diverse fungi, but the structure and component set vary by lineage. [PMID:25002088]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which immobile plasma-membrane eisosomes were first named and the plasma-membrane protein Sur7 was localized to those domains. [DOI:10.1038/nature04472]

Functions

plasma-membrane domain organization — Eisosomes scaffold stable furrow-like MCC domains in the fungal plasma membrane.
- DOI:10.1083/jcb.201104040 Karotki et al. 2011 connected Pil1/Lsp1 filament assembly to a membrane scaffold at eisosomes.
- PMID:25002088 Douglas and Konopka 2014 reviewed MCC/eisosomes as stable plasma-membrane domains in fungi.

Mechanism graphs

Pil1/Lsp1 filaments scaffold MCC/eisosome furrows (ASSEMBLY)

Pil1/Lsp1 BAR-domain proteins assemble into eisosome filaments on the cytoplasmic face of MCC membrane domains, producing a paired protein scaffold and plasma-membrane furrow.

Subject	Predicate	Object	Evidence
Pil1/Lsp1 BAR-domain eisosome core	assembles into	eisosome filament	`DOI:10.1091/mbc.e10-12-1021` Olivera-Couto et al. 2011 established Pil1 and Lsp1 as the BAR-domain core components of Saccharomyces cerevisiae eisosomes.
Pil1/Lsp1 BAR-domain eisosome core	scaffolds	eisosome membrane domain/MCC	`DOI:10.1083/jcb.201104040` Karotki et al. 2011 showed that purified Pil1 and Lsp1 assemble into eisosome-like membrane scaffolds.
Sur7 MCC integral membrane protein	localizes to	eisosome membrane domain/MCC	`DOI:10.1038/nature04472` Walther et al. 2006 found that the plasma-membrane protein Sur7 localizes to eisosomes.

Discussions

CURATION_TODO (OPEN): Resolve exact family groundings for Sur7 and other integral membrane proteins of MCC/eisosome domains. This first record includes the experimentally established Sur7 MCC marker, but no exact source-neutral family CURIE was curated for the Sur7-family membrane proteins. Nce102 and additional MCC/eisosome residents should be added only after their component boundaries and exact family groundings are resolved.

Evidence

GO:0032126 Gene Ontology cellular-component term for eisosome.
GO:0036286 Gene Ontology cellular-component term for eisosome filament.
GO:0090512 Gene Ontology cellular-component term for eisosome membrane domain/MCC.
DOI:10.1038/nature04472 Walther et al. 2006, Eisosomes mark static sites of endocytosis, Nature.
DOI:10.1091/mbc.e08-03-0313 Moreira et al. 2009, Pil1 Controls Eisosome Biogenesis, Molecular Biology of the Cell.
DOI:10.1091/mbc.e10-12-1021 Olivera-Couto et al. 2011, The eisosome core is composed of BAR domain proteins, Molecular Biology of the Cell.
DOI:10.1083/jcb.201104040 Karotki et al. 2011, Eisosome proteins assemble into a membrane scaffold, Journal of Cell Biology.
PMID:25002088 Douglas and Konopka 2014, Fungal membrane organization: the eisosome concept, Annual Review of Microbiology.

Curation history

2026-09-10T10:54:49Z claude · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-10T10:56:47Z claude · EXPANDED_RECORD — Added eisosome filament and MCC has_part links, Pil1/Lsp1 and Sur7 constituents, fungal taxonomic scope, a Saccharomyces cerevisiae canonical example, a plasma-membrane-domain organization function, record-level literature evidence, an MCC scaffold assembly graph and a grounding TODO for Sur7-family membrane proteins.
2026-09-10T11:04:19Z claude · ADDRESS_REVIEW — Resolved #351 by removing GO-only whole-part terminal edges from the eisosome assembly graph; resolved #352 by narrowing the Saccharomyces cerevisiae canonical example to the discovery and Sur7-localization claims directly supported by Walther et al. 2006.
2026-09-21T12:05:18Z codex · REPLACED_UNREADABLE_EVIDENCE — Resolved #1239 by routing Douglas and Konopka 2014 fungal MCC/eisosome evidence through reachable PMID:25002088 instead of the unreadable Annual Reviews DOI.

Source: data/structures/other/eisosome.yaml