anammoxosome membrane

cellstructuremech:anammoxosome_membrane · Membrane organelle · Membrane · Proposed

The single ladderane-lipid-containing bilayer membrane that surrounds the anammoxosome. [DOI:10.1111/1574-6976.12014]

Part of: anammoxosome (GO:0044222)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
ladderane lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Dense ladderane-rich lipid bilayer that bounds the anammoxosome and separates its hydrazine-producing matrix from the cytoplasm. `DOI:10.1111/1574-6976.12014` Kartal et al. 2013 review the anammoxosome as an intracytoplasmic organelle bounded by ladderane lipids. `PMID:15098544` Sinninghe Damste et al. 2002 identified ladderane lipids as membrane lipids specific to anammox bacteria.

Taxonomic distribution

NCBITaxon:203682 Planctomycetota — RARE: Anammoxosome membranes are restricted to anaerobic ammonium-oxidizing members of the Brocadiales rather than all Planctomycetota. [DOI:10.1111/1574-6976.12014]
NCBITaxon:2 Bacteria — RARE: The membrane is known from anammox bacteria that build ladderane-bounded anammoxosomes. [DOI:10.1111/1574-6976.12014]

Canonical examples

NCBITaxon:174633 Candidatus Kuenenia stuttgartiensis — Model anammox bacterium used for immunogold localization of anammoxosome enzymes and for proteomic analyses of the anammoxosome compartment. [DOI:10.1128/JB.00186-15]

Functions

anammoxosome permeability barrier — The anammoxosome membrane forms a ladderane-rich boundary around an organelle that confines hydrazine metabolism and supports energy conservation across the membrane.
- DOI:10.1111/1574-6976.12014 Kartal et al. 2013 review the anammoxosome membrane as the ladderane-rich boundary for the anammox energy-conserving compartment.
- PMID:15098544 Sinninghe Damste et al. 2002 identified ladderane lipids as unusually dense membrane lipids of anammox bacteria.

Mechanism graphs

Anammoxosome membrane encloses a ladderane-bounded compartment (FUNCTION)

The anammoxosome membrane is a ladderane-lipid-containing bilayer that surrounds the anammoxosome compartment used for hydrazine metabolism and energy conservation.

Subject	Predicate	Object	Evidence
anammoxosome membrane	is part of	anammoxosome	`DOI:10.1111/1574-6976.12014` Kartal et al. 2013 review ladderane lipids as the signature anammoxosome membrane lipids.
anammoxosome membrane	compartmentalizes	anammoxosome hydrazine metabolism	`DOI:10.1111/1574-6976.12014` Kartal et al. 2013 review the anammoxosome as the organelle that compartmentalizes anaerobic ammonium oxidation. `DOI:10.1128/JB.00186-15` Kartal et al. 2015 localized key hydrazine-pathway enzymes in the anammoxosome of Candidatus Kuenenia stuttgartiensis.

Discussions

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the generic ladderane-lipid bilayer constituent of the anammoxosome membrane. The source literature identifies ladderane lipids as signature anammoxosome-membrane constituents, but no exact CURIE was curated for the complete ladderane-lipid bilayer.

Evidence

GO:0016020 Gene Ontology cellular-component parent term for membrane.
GO:0044222 Gene Ontology cellular-component term for the containing anammoxosome.
DOI:10.1111/1574-6976.12014 Kartal B, de Almeida NM, Maalcke WJ, Op den Camp HJM, Jetten MSM and Keltjens JT 2013, How to make a living from anaerobic ammonium oxidation, FEMS Microbiology Reviews.
DOI:10.1128/JB.00186-15 Kartal et al. 2015, Immunogold localization of key metabolic enzymes in the anammoxosome and on the tubule-like structures of Kuenenia stuttgartiensis, Journal of Bacteriology.
PMID:15098544 Sinninghe Damste et al. 2002 identified ladderane lipid membrane components in anammox bacteria.

Curation history

2026-09-13T15:43:16Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-13T15:43:54Z codex · EXPANDED_RECORD — Added SL-0492 xref, membrane parentage, anammoxosome parthood, a label-only ladderane-lipid-bilayer component, Planctomycetota/Bacteria scope, a Kuenenia example, a permeability-barrier function, UniProt/GO/DOI/PMID evidence, a nonmechanistic anammoxosome-membrane topology graph, and a ladderane-lipid-bilayer grounding TODO.
2026-09-13T15:47:48Z codex · EDITED_RECORD — Removed stale UniProt SL-0492 xref and evidence after live identifier validation reported the accession as unresolved; retargeted definition, component, graph-edge, and TODO evidence to DOI/PMID literature.
2026-09-13T15:48:15Z codex · EDITED_RECORD — Deduplicated replacement Kartal et al. 2013 evidence on the ladderane-lipid-bilayer component and anammoxosome parthood edge.

Source: data/structures/membrane_organelle/anammoxosome_membrane.yaml