apicomplexan dense granule membrane

GO:0030668 · Membrane organelle · Membrane · Proposed

The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites. [GO:0030668]

Part of: apicomplexan dense granule (GO:0020026)

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
dense granule lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Generic lipid-bilayer constituent that surrounds an apicomplexan dense granule and separates its secretory lumen from the parasite cytosol. `GO:0030668` GO:0030668 defines the apicomplexan dense granule membrane as the lipid bilayer surrounding an apicomplexan dense granule. `DOI:10.1111/jeu.12904` Griffith et al. 2022 review Toxoplasma dense-granule biogenesis, secretion, and membrane-bounded organelle function.

NCBITaxon:5794 Apicomplexa — COMMON: Dense granule membranes bound the dense granules used by apicomplexan parasites to store and secrete dense-granule cargo proteins. [DOI:10.1016/j.ijpara.2005.03.011]

NCBITaxon:5811 Toxoplasma gondii — Apicomplexan model in which dense-granule biogenesis, secretion, and post-Golgi trafficking to a membrane-bounded dense granule have been reviewed. [DOI:10.1111/jeu.12904]

dense granule boundary — The dense granule membrane forms the lipid-bilayer boundary around an apicomplexan dense granule.
- GO:0030668 GO:0030668 defines the apicomplexan dense granule membrane as the lipid bilayer surrounding a dense granule of this type.
- GO:0020026 GO:0020026 defines the apicomplexan dense granule as a secretory organelle with a granular internal matrix.

The apicomplexan dense granule membrane is the lipid bilayer that bounds the dense granule.

Subject	Predicate	Object	Evidence
apicomplexan dense granule membrane	is part of	apicomplexan dense granule	`GO:0030668` GO:0030668 defines the apicomplexan dense granule membrane as surrounding an apicomplexan dense granule. `DOI:10.1111/jeu.12904` Griffith et al. 2022 review dense granules as membrane-bounded organelles in Toxoplasma.

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the generic lipid constituent of the apicomplexan dense granule membrane. The record is exactly grounded to GO:0030668, but no dense-granule-specific lipid or lipid-bilayer CURIE was curated for the membrane constituent.

GO:0030668 Gene Ontology cellular-component term for the apicomplexan dense granule membrane.
GO:0031090 Gene Ontology cellular-component parent term for organelle membrane.
GO:0020026 Gene Ontology cellular-component term for the apicomplexan dense granule.
DOI:10.1111/jeu.12904 Griffith et al. 2022, Dense granule biogenesis, secretion, and function in Toxoplasma gondii, Journal of Eukaryotic Microbiology.
DOI:10.1016/j.ijpara.2005.03.011 Mercier et al. 2005, Dense granules: are they key organelles to help understand the parasitophorous vacuole of all apicomplexa parasites?, International Journal for Parasitology.

2026-09-15T21:25:35Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-15T21:26:16Z codex · EXPANDED_RECORD — Added organelle-membrane parentage, dense-granule parthood, a label-only dense-granule lipid bilayer component, Apicomplexa and Toxoplasma gondii scope, a boundary function, GO/DOI evidence, a nonmechanistic dense-granule-membrane topology graph, and a lipid-grounding TODO.
2026-09-15T21:39:07Z codex · ADDRESS_REVIEW — Addressed PR #1027 review issues #1028 and #1029 by narrowing the dense-granule membrane graph to boundary topology and replacing Toxoplasma-style GRA wording in the Apicomplexa distribution row with source-neutral dense-granule cargo language.