COPI-coated vesicle membrane

GO:0030663 · Membrane organelle · Membrane · Proposed

The lipid bilayer surrounding a COPI-coated vesicle. [GO:0030663]

Synonyms: COPI coated vesicle membrane

Part of: COPI-coated vesicle (GO:0030137)

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
COPI-coated vesicle membrane lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Lipid-bilayer constituent of the COPI-coated vesicle membrane that surrounds a COPI-coated vesicle. `GO:0030663` GO:0030663 defines the COPI-coated vesicle membrane as the lipid bilayer surrounding a COPI-coated vesicle.

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast has a coatomer-dependent COPI system that retrieves dilysine-tagged early secretory cargo to the endoplasmic reticulum. [DOI:10.1091/mbc.e02-11-0736]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which coatomer mutants established COPI roles in Golgi-to-ER retrieval and early secretory trafficking. [DOI:10.1091/mbc.e02-11-0736]

The COPI-coated vesicle membrane is the lipid-bilayer boundary of the COPI-coated vesicle formed during Golgi membrane evagination.

Subject	Predicate	Object	Evidence
COPI-coated vesicle membrane	is part of	COPI-coated vesicle	`GO:0030663` GO:0030663 identifies the COPI-coated vesicle membrane as part of a COPI-coated vesicle. `GO:0030137` GO:0030137 identifies the containing COPI-coated vesicle.
COPI-coated vesicle membrane	bounds	COPI-coated vesicle	`GO:0030663` GO:0030663 defines the COPI-coated vesicle membrane as the lipid bilayer surrounding a COPI-coated vesicle.
Golgi membrane	donates membrane to	COPI-coated vesicle membrane	`GO:0035964` GO:0035964 defines COPI-coated vesicle budding as evagination of a Golgi membrane to form a COPI-coated vesicle.

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the lipid constituent of the COPI-coated vesicle membrane. The record is exactly grounded to GO:0030663, but the COPI-coated vesicle membrane lipid-bilayer constituent is intentionally left as reviewed-label-only until an exact source-neutral lipid or membrane-constituent CURIE is curated.
INTERPRETATION (RESOLVED): Keep the COPI vesicle coat as a whole-vesicle part rather than as a lipid-bilayer membrane component. GO:0030126 denotes the COPI protein coat on the whole coated vesicle, whereas GO:0030663 denotes the lipid bilayer surrounding that vesicle.

GO:0030663 Gene Ontology cellular-component term for the COPI-coated vesicle membrane.
GO:0030660 Gene Ontology cellular-component parent term for Golgi-associated vesicle membranes.
GO:0030662 Gene Ontology cellular-component parent term for coated vesicle membranes.
GO:0030137 Gene Ontology cellular-component term for the containing COPI-coated vesicle.
GO:0000139 Gene Ontology cellular-component term for the Golgi membrane source of COPI-coated vesicle budding.
GO:0035964 Gene Ontology biological-process term for COPI-coated vesicle budding.
GO:0030126 Gene Ontology cellular-component term for the COPI vesicle coat that surrounds COPI-coated vesicles.
DOI:10.1091/mbc.e02-11-0736 Sandmann et al. 2003, Suppression of Coatomer Mutants by a New Protein Family with COPI and COPII Binding Motifs in Saccharomyces cerevisiae, Molecular Biology of the Cell.

2026-09-14T18:20:13Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-14T18:20:57Z codex · EXPANDED_RECORD — Added GO vesicle-membrane parentage, COPI-coated-vesicle parthood, the exact GO synonym, a reviewed-label-only lipid-bilayer component, Saccharomyces scope, GO/DOI evidence, a nonmechanistic vesicle-membrane topology graph, and lipid-grounding plus COPI-coat boundary discussions.
2026-09-14T18:37:24Z codex · REVIEW_FIX — Addressed issue #887 by removing the unused COPI-coated vesicle budding node from the topology graph while retaining GO:0035964 as edge evidence for Golgi membrane donation.
2026-09-21T11:01:21Z codex · REPLACED_UNREADABLE_EVIDENCE — Resolved #1235 by replacing unreadable COPI citations with reachable Sandmann et al. 2003 Golgi-to-ER retrieval evidence and removing redundant Serafini Golgi-budding citations already covered by GO evidence.