COPII-coated ER to Golgi transport vesicle

GO:0030134 · Membrane organelle · Membrane bounded organelle · Proposed

A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport). [GO:0030134]

Synonyms: COPII-associated ER to Golgi transport vesicle; COPII-associated vesicle; COPII-coated vesicle; COPII vesicle; ER to Golgi transport vesicle; ER-Golgi transport vesicle; endoplasmic reticulum to Golgi transport vesicle

Has part: COPII vesicle coat (GO:0030127)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast forms COPII-coated ER-to-Golgi transport vesicles from endoplasmic-reticulum membranes using the Sec23/Sec24, Sec13/Sec31, and Sar1 COPII coat machinery. [PMID:8004676]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which Sec proteins were identified as COPII coat machinery that drives ER-derived vesicle budding. [PMID:8004676]

Functions

endoplasmic reticulum to Golgi vesicle-mediated transport GO:0006888 — COPII-coated ER-to-Golgi transport vesicles act as anterograde carriers that move cargo from the endoplasmic reticulum to the Golgi apparatus.
- GO:0006888 GO:0006888 defines ER-to-Golgi vesicle-mediated transport as movement from the ER to the Golgi mediated by COPII vesicles.
- GO:0030134 GO:0030134 defines COPII-coated ER-to-Golgi transport vesicles as anterograde protein carriers from rough ER to Golgi apparatus.

Mechanism graphs

COPII-coated vesicle topology (FUNCTION)

The COPII vesicle coat assembles on endoplasmic-reticulum membrane to produce coated vesicles that mediate ER-to-Golgi transport.

Subject	Predicate	Object	Evidence
COPII vesicle coat	is part of	COPII-coated ER to Golgi transport vesicle	`GO:0030134` GO:0030134 defines this vesicle by its COPII coat complex.
endoplasmic reticulum membrane	evaginates into	COPII-coated ER to Golgi transport vesicle	`GO:0090114` GO:0090114 defines COPII-coated vesicle budding as evagination of ER membrane to form a COPII-coated vesicle. `PMID:9568718` Matsuoka et al. 1998 reconstituted COPII-coated vesicle formation on defined liposomes.
COPII-coated ER to Golgi transport vesicle	transports cargo to	Golgi apparatus	`GO:0030134` GO:0030134 describes COPII-associated vesicles as ER-to-Golgi anterograde transport carriers.
COPII vesicle coat	participates in	COPII-coated vesicle budding	`PMID:8004676` Barlowe et al. 1994 identified Sec proteins as a COPII membrane coat that drives ER vesicle budding. `GO:0090114` GO:0090114 denotes the budding process that forms COPII-coated vesicles.
COPII-coated ER to Golgi transport vesicle	participates in	endoplasmic reticulum to Golgi vesicle-mediated transport	`GO:0006888` GO:0006888 defines ER-to-Golgi vesicle-mediated transport as movement from the ER to the Golgi mediated by COPII vesicles. `GO:0030134` GO:0030134 identifies COPII-coated ER-to-Golgi transport vesicles as the anterograde carriers.

Evidence

GO:0030134 Gene Ontology cellular-component term for COPII-coated ER-to-Golgi transport vesicles.
GO:0030135 Gene Ontology cellular-component parent term for coated vesicles.
GO:0030127 Gene Ontology cellular-component term for the COPII vesicle coat carried by the vesicle.
GO:0090114 Gene Ontology biological-process term for COPII-coated vesicle budding.
GO:0006888 Gene Ontology biological-process term for ER-to-Golgi vesicle-mediated transport by COPII vesicles.
PMID:8004676 Barlowe et al. 1994, 'COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum', Cell.
PMID:9568718 Matsuoka et al. 1998, 'COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes', Cell.

Curation history

2026-09-14T01:11:49Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-14T01:12:38Z codex · EXPANDED_RECORD — Added GO coated-vesicle parentage, COPII coat parthood, GO synonyms, Saccharomyces scope, COPII budding function, GO/DOI evidence, and a nonmechanistic ER-to-Golgi vesicle topology graph.
2026-09-14T01:22:34Z codex · ADDRESS_PR_REVIEW — Addressed issue #861 by replacing the vesicle-creation function with GO:0006888 ER-to-Golgi vesicle-mediated transport while retaining COPII budding as topology evidence.
2026-09-21T09:25:14Z codex · REPLACED_UNREADABLE_EVIDENCE — Resolved #1229 by routing Barlowe et al. 1994 COPII evidence through reachable PMID:8004676 instead of the unreadable Cell DOI.
2026-09-21T11:34:06Z codex · REPLACED_UNREADABLE_EVIDENCE — Resolved #1237 by routing Matsuoka et al. 1998 COPII liposome evidence through reachable PMID:9568718 instead of the unreadable Cell DOI.

Source: data/structures/membrane_organelle/copii_coated_er_to_golgi_transport_vesicle.yaml