Cvt vesicle membrane

GO:0033110 · Membrane organelle · Membrane · Proposed

Either lipid bilayer membrane surrounding a Cvt vesicle, a double membrane-layered vesicle implicated in the cytoplasm to vacuole targeting pathway. [GO:0033110]

Part of: Cvt vesicle (GO:0033107)

Xrefs: uniprot.location:SL-0081 — Cvt vesicle membrane

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
Cvt vesicle lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	One of the two lipid bilayers surrounding a Cvt vesicle before vesicle-vacuole fusion. `GO:0033110` GO:0033110 defines the Cvt vesicle membrane as either lipid bilayer surrounding a Cvt vesicle. `uniprot.location:SL-0081` — Cvt vesicle membrane UniProt SL-0081 maps directly to GO:0033110 and describes the membrane surrounding a double-membrane Cvt vesicle. `PMID:15004240` Reggiori et al. 2004 describe Cvt vesicles as double-membrane cytosolic carriers in budding yeast.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Double-membrane Cvt vesicles have been characterized in budding yeast during cytoplasm-to-vacuole targeting. [PMID:15004240]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Primary yeast model used to define double-membrane Cvt vesicle formation and vacuolar delivery. [PMID:15004240]

Functions

cytoplasm to vacuole targeting by the Cvt pathway GO:0032258 — The Cvt vesicle membrane surrounds the selective hydrolase cargo carrier used for cytoplasm-to-vacuole targeting.
- GO:0032258 GO:0032258 defines Cvt-pathway delivery by Atg19-dependent formation of a Cvt complex and membrane expansion around it.
- DOI:10.1074/jbc.M404399200 Shintani and Klionsky 2004 analyzed Cvt cargo and its effect on Cvt vesicle formation.

Mechanism graphs

Cvt vesicle membranes surround the yeast Cvt cargo carrier (FUNCTION)

A pair of Cvt vesicle membranes forms the double-membrane carrier that sequesters Cvt cargo before vacuolar delivery.

Subject	Predicate	Object	Evidence
Cvt vesicle membrane	is part of	Cvt vesicle	`GO:0033110` GO:0033110 defines the Cvt vesicle membrane as either bilayer surrounding the vesicle. `uniprot.location:SL-0081` — Cvt vesicle membrane UniProt SL-0081 places the Cvt vesicle membrane under the Cvt vesicle.
Cvt complex	is enclosed by	Cvt vesicle	`GO:0032258` GO:0032258 defines the Cvt pathway as membrane expansion around the Cvt complex.
Cvt vesicle	supports	cytoplasm to vacuole targeting by the Cvt pathway	`GO:0033107` GO:0033107 defines Cvt vesicles by their implication in the Cvt pathway. `DOI:10.1074/jbc.M404399200` Shintani and Klionsky 2004 describe Cvt cargo incorporation into forming vesicles.

Discussions

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the lipid constituent of either Cvt vesicle membrane bilayer. The record is exactly grounded to GO:0033110 and UniProt SL-0081, but no exact source-neutral CURIE was curated for the generic lipid constituent of either surrounding Cvt vesicle bilayer.

Evidence

GO:0033110 Gene Ontology cellular-component term for either bilayer of the Cvt vesicle membrane.
GO:0030659 Gene Ontology cellular-component parent term for cytoplasmic vesicle membrane.
GO:0033107 Gene Ontology cellular-component term for the Cvt vesicle that this membrane surrounds.
GO:0032258 Gene Ontology biological-process term for cytoplasm to vacuole targeting by the Cvt pathway.
GO:0034270 Gene Ontology cellular-component term for the Cvt complex cargo node sequestered by completed Cvt vesicles.
uniprot.location:SL-0081 — Cvt vesicle membrane UniProt Subcellular Location entry SL-0081 maps directly to GO:0033110, places it under Cvt vesicle, and describes the membrane surrounding a double-membrane Cvt vesicle.
DOI:10.1091/mbc.e03-07-0479 Reggiori et al. 2004, Early stages of the secretory pathway, but not endosomes, are required for Cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae, Molecular Biology of the Cell.
DOI:10.1074/jbc.M404399200 Shintani and Klionsky 2004, Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway, Journal of Biological Chemistry.

Curation history

2026-09-12T22:59:24Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-12T23:00:08Z codex · EXPANDED_RECORD — Added cytoplasmic vesicle membrane parentage, Cvt vesicle parthood, the UniProt SL-0081 xref, a reviewed-label-only lipid-bilayer component, budding-yeast distribution, a Cvt-pathway function, a nonmechanistic Cvt-delivery graph, and a lipid-grounding TODO.
2026-09-12T23:11:36Z codex · ADDRESS_REVIEW — Resolved #718 by adding GO:0034270 to the record-level evidence list for the Cvt complex node used in the causal graph.

Source: data/structures/membrane_organelle/cvt_vesicle_membrane.yaml