endocytic vesicle lumen

GO:0071682 · Membrane organelle · Subcellular region · Proposed

The volume enclosed by the membrane of an endocytic vesicle. [GO:0071682]

Part of: endocytic vesicle (GO:0030139)

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast forms endocytic vesicles at cortical actin-based sites; the lumen is the bounded volume inside those endocytic carriers. [DOI:10.1016/j.devcel.2005.04.014]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast cortical endocytic sites were used to characterize the ordered actin and coat modules that form endocytic vesicles. [DOI:10.1016/j.cell.2005.09.024]

The endocytic vesicle lumen is the bounded volume enclosed by the endocytic vesicle membrane inside an endocytic vesicle.

Subject	Predicate	Object	Evidence
endocytic vesicle lumen	is part of	endocytic vesicle	`GO:0071682` GO:0071682 identifies the volume enclosed by an endocytic vesicle membrane. `GO:0030139` GO:0030139 identifies the enclosing endocytic vesicle.
endocytic vesicle membrane	bounds	endocytic vesicle lumen	`GO:0030666` GO:0030666 identifies the membrane surrounding an endocytic vesicle. `GO:0071682` GO:0071682 defines the lumen by enclosure within the endocytic vesicle membrane.

INTERPRETATION (RESOLVED): Use the cytoplasmic vesicle lumen rather than the generic intracellular organelle lumen as the curated parent. GO asserts GO:0071682 as part of an endocytic vesicle and directly under the broad intracellular organelle lumen. Because GO:0030139 endocytic vesicle is a cytoplasmic vesicle, GO:0060205 is the narrower inferred lumen parent that keeps endocytic vesicle lumen with the other cytoplasmic vesicle lumen subtypes in this corpus.
INTERPRETATION (RESOLVED): Keep variable internalized cargo out of the endocytic vesicle lumen record. GO:0071682 denotes the bounded volume inside an endocytic vesicle rather than a stable molecular cargo class, and the cargo enclosed by an endocytic carrier depends on the uptake event and subtype.

GO:0071682 Gene Ontology cellular-component term for the endocytic vesicle lumen.
GO:0060205 Gene Ontology cellular-component parent term for cytoplasmic vesicle lumens.
GO:0030139 Gene Ontology cellular-component term for the enclosing endocytic vesicle.
GO:0031410 Gene Ontology cellular-component term for the broader cytoplasmic vesicle class that includes endocytic vesicles.
GO:0030666 Gene Ontology cellular-component term for the membrane that bounds an endocytic vesicle lumen.
GO:0106176 Gene Ontology cellular-component child term for clathrin-coated endocytic vesicle lumens.
DOI:10.1016/j.devcel.2005.04.014 Newpher et al. 2005, In Vivo Dynamics of Clathrin and Its Adaptor-Dependent Recruitment to the Actin-Based Endocytic Machinery in Yeast, Developmental Cell.
DOI:10.1016/j.cell.2005.09.024 Kaksonen, Toret and Drubin 2005, A Modular Design for the Clathrin- and Actin-Mediated Endocytosis Machinery, Cell.

2026-09-16T10:58:05Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-16T10:59:24Z codex · EXPANDED_RECORD — Added cytoplasmic-vesicle-lumen parentage, endocytic-vesicle parthood, Saccharomyces endocytic-site scope, GO/DOI evidence, a nonmechanistic lumen topology graph, and a resolved cargo-boundary discussion.
2026-09-16T11:10:29Z codex · ADDRESSED_PR_REVIEW — Resolved issue #1089 by documenting why GO:0060205 is the curated cytoplasmic-vesicle-lumen parent and by adding GO:0031410 support for the endocytic-vesicle to cytoplasmic-vesicle inference.