endoplasmic reticulum membrane

GO:0005789 · Membrane organelle · Membrane · Proposed

The lipid bilayer surrounding the endoplasmic reticulum. [GO:0005789]

Synonyms: ER membrane

Part of: endoplasmic reticulum (GO:0005783)

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
endoplasmic reticulum lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Lipid-bilayer constituent of the endoplasmic reticulum membrane that surrounds the ER lumen. `GO:0005789` GO:0005789 defines the endoplasmic reticulum membrane as the lipid bilayer surrounding the endoplasmic reticulum.

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast forms COPII-coated vesicles from endoplasmic-reticulum membranes using the Sar1 and Sec23/Sec24-Sec13/Sec31 COPII coat machinery. [PMID:8004676]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model used to characterize Sec61-dependent protein insertion into the endoplasmic reticulum membrane. [DOI:10.1091/mbc.3.2.129]

The endoplasmic reticulum membrane bounds the ER lumen, embeds Sec61 translocons, and donates membrane for COPII-coated vesicle budding.

Subject	Predicate	Object	Evidence
endoplasmic reticulum membrane	is part of	endoplasmic reticulum	`GO:0005789` GO:0005789 defines the ER membrane as the lipid bilayer surrounding the ER.
endoplasmic reticulum membrane	bounds	endoplasmic reticulum lumen	`GO:0005788` GO:0005788 defines the ER lumen as the volume enclosed by ER membranes.
Sec61 translocon complex	is embedded in	endoplasmic reticulum membrane	`GO:0005784` GO:0005784 identifies Sec61 as an endoplasmic reticulum translocon complex. `DOI:10.1091/mbc.3.2.129` Stirling et al. 1992 characterized sec61 mutants defective in integral membrane protein insertion into the ER.
COPII vesicle coat	assembles on	endoplasmic reticulum membrane	`GO:0090114` GO:0090114 defines COPII-coated vesicle budding as evagination of ER membrane to form a COPII-coated vesicle. `PMID:9568718` Matsuoka et al. 1998 reconstituted COPII-coated vesicle formation on chemically defined liposomes.

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the lipid constituent of the endoplasmic reticulum membrane. The record is exactly grounded to GO:0005789, but the ER lipid bilayer constituent is intentionally left as reviewed-label-only until an exact source-neutral lipid or membrane-constituent CURIE is curated.

GO:0005789 Gene Ontology cellular-component term for endoplasmic reticulum membrane.
GO:0016020 Gene Ontology cellular-component parent term for membrane.
GO:0005783 Gene Ontology cellular-component term for endoplasmic reticulum.
GO:0005788 Gene Ontology cellular-component term for endoplasmic reticulum lumen.
GO:0005784 Gene Ontology cellular-component term for the Sec61 translocon complex.
GO:0090114 Gene Ontology biological-process term for COPII-coated vesicle budding.
DOI:10.1091/mbc.3.2.129 Stirling et al. 1992, 'Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum', Molecular Biology of the Cell.
PMID:8004676 Barlowe et al. 1994, 'COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum', Cell.
PMID:9568718 Matsuoka et al. 1998, 'COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes', Cell.

2026-09-14T03:04:35Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-14T03:05:07Z codex · EXPANDED_RECORD — Added the GO exact ER membrane synonym, generic membrane parentage, endoplasmic-reticulum parthood, a reviewed-label-only ER lipid bilayer component, Saccharomyces scope, GO/DOI evidence, a nonmechanistic ER membrane topology graph, and a lipid-grounding TODO.
2026-09-14T03:11:09Z codex · ADDRESS_REVIEW — Resolved #872 by narrowing the Saccharomyces taxonomic-scope note to the COPII budding claim directly supported by the Barlowe et al. 1994 reference.
2026-09-21T09:25:14Z codex · REPLACED_UNREADABLE_EVIDENCE — Resolved #1229 by routing Barlowe et al. 1994 COPII evidence through reachable PMID:8004676 instead of the unreadable Cell DOI.
2026-09-21T11:34:06Z codex · REPLACED_UNREADABLE_EVIDENCE — Resolved #1237 by routing Matsuoka et al. 1998 COPII liposome evidence through reachable PMID:9568718 instead of the unreadable Cell DOI.