esterosome lumen

GO:0034467 · Membrane organelle · Subcellular region · Proposed

The volume enclosed by the esterosome membrane. [GO:0034467]

Synonyms: esterosomal lumen

Part of: esterosome (GO:0033117)

Xrefs: uniprot.location:SL-0328 — Esterosome lumen

Taxonomic distribution

NCBITaxon:44689 Dictyostelium discoideum — COMMON: Dictyostelium discoideum aggregation-stage cells form esterosome lumina occupied by crystalline esterase-like proteins. [DOI:10.1083/jcb.110.3.669]

NCBITaxon:44689 Dictyostelium discoideum — Social amoeba model in which esterosome lumina contain crystal protein and D2 protein cargo enclosed by an RER-like membrane. [DOI:10.1083/jcb.110.3.669]

esterosome crystal storage — The esterosome lumen is the internal compartment occupied by crystalline esterase-like protein cargo.
- DOI:10.1083/jcb.110.3.669 Bomblies et al. 1990 purified Dictyostelium esterosome crystals and localized the crystal protein and D2 protein to membrane-enclosed crystalline compartments.

The esterosome lumen is the internal esterosome compartment enclosed by the esterosome membrane.

Subject	Predicate	Object	Evidence
esterosome lumen	is part of	esterosome	`GO:0034467` GO:0034467 identifies the esterosome lumen cellular component. `uniprot.location:SL-0328` — Esterosome lumen UniProt SL-0328 places the esterosome lumen under the esterosome subcellular location. `GO:0033117` GO:0033117 identifies the containing esterosome.
esterosome membrane	encloses	esterosome lumen	`GO:0034467` GO:0034467 defines the esterosome lumen as the volume enclosed by the esterosome membrane. `GO:0033118` GO:0033118 identifies the lipid bilayer surrounding an esterosome. `DOI:10.1083/jcb.110.3.669` Bomblies et al. 1990 showed that Dictyostelium esterosome crystals are membrane-enclosed.

INTERPRETATION (RESOLVED): Keep the esterosome membrane as the boundary of the esterosome lumen rather than as a lumen component. GO:0034467 denotes the volume enclosed by the esterosome membrane, whereas GO:0033118 denotes the membrane surrounding an esterosome.

GO:0034467 Gene Ontology cellular-component term for esterosome lumen.
GO:0043233 Gene Ontology cellular-component term for organelle lumen, the broader organelle-enclosed compartment parent.
GO:0033117 Gene Ontology cellular-component term for the containing esterosome.
GO:0033118 Gene Ontology cellular-component term for the esterosome membrane that encloses the lumen.
uniprot.location:SL-0328 — Esterosome lumen UniProt Subcellular Location entry SL-0328 maps directly to GO:0034467, places the esterosome lumen under the esterosome subcellular location, and lists esterosomal lumen as an exact synonym.
uniprot.location:SL-0109 — Esterosome UniProt Subcellular Location entry SL-0109 maps the esterosome to GO:0033117.
uniprot.location:SL-0108 — Esterosome membrane UniProt Subcellular Location entry SL-0108 maps the esterosome membrane to GO:0033118.
DOI:10.1083/jcb.110.3.669 Bomblies et al. 1990, Membrane-enclosed crystals in Dictyostelium discoideum cells, consisting of developmentally regulated proteins with sequence similarities to known esterases, Journal of Cell Biology.

2026-09-13T14:22:55Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-13T14:23:38Z codex · EXPANDED_RECORD — Added the esterosomal lumen synonym and UniProt SL xref, organelle-lumen parentage, esterosome parthood, Dictyostelium scope, Dictyostelium as a canonical example, a crystal-storage function, GO/UniProt/DOI evidence, a nonmechanistic lumen-topology graph, and a resolved boundary interpretation.