glycosome lumen

GO:0034468 · Membrane organelle · Subcellular region · Proposed

The volume enclosed by the glycosome membrane. [GO:0034468]

Synonyms: glycosomal lumen; glycosomal matrix; glycosome matrix

Part of: glycosome (GO:0020015)

Xrefs: uniprot.location:SL-0332 — Glycosome matrix

Taxonomic distribution

NCBITaxon:5653 Kinetoplastea — COMMON: Glycosome lumina are the matrix compartments of specialized peroxisomes in kinetoplastid protists. [DOI:10.1016/j.bbamcr.2015.09.015]

NCBITaxon:5691 Trypanosoma brucei — Kinetoplastid parasite whose glycosome lumen houses glycolytic enzymes required to maintain controlled glucose catabolism. [DOI:10.1073/pnas.0806664105]

glycosome lumen glycolysis — The glycosome lumen is the matrix compartment that contains major glycolytic enzymes and thereby compartmentalizes glycolytic flux in kinetoplastids.
- DOI:10.1016/0014-5793(77)80476-6 Opperdoes and Borst 1977 localized nine glycolytic enzymes to Trypanosoma brucei glycosomes.
- DOI:10.1073/pnas.0806664105 Haanstra et al. 2008 showed that mislocalizing glycosomal enzymes disrupts glycolytic control in Trypanosoma brucei.

The glycosome lumen is the internal glycosome compartment enclosed by the glycosome membrane.

Subject	Predicate	Object	Evidence
glycosome lumen	is part of	glycosome	`GO:0034468` GO:0034468 identifies the glycosome lumen cellular component. `uniprot.location:SL-0332` — Glycosome matrix UniProt SL-0332 places the glycosome matrix under the glycosome subcellular location. `GO:0020015` GO:0020015 identifies the containing glycosome.
glycosome membrane	encloses	glycosome lumen	`GO:0034468` GO:0034468 defines the glycosome lumen as the volume enclosed by the glycosome membrane. `GO:0046860` GO:0046860 identifies the membrane surrounding a glycosome. `DOI:10.1016/j.bbamcr.2015.09.015` Haanstra et al. 2016 review glycosomes as membrane-bounded specialized peroxisomes.

INTERPRETATION (RESOLVED): Keep the glycosome membrane as the boundary of the glycosome lumen rather than as a lumen component. GO:0034468 denotes the volume enclosed by the glycosome membrane, whereas GO:0046860 denotes the membrane surrounding a glycosome.

GO:0034468 Gene Ontology cellular-component term for glycosome lumen.
GO:0043233 Gene Ontology cellular-component term for organelle lumen, the broader organelle-enclosed compartment parent.
GO:0020015 Gene Ontology cellular-component term for the containing glycosome.
GO:0046860 Gene Ontology cellular-component term for the glycosome membrane that encloses the lumen.
uniprot.location:SL-0332 — Glycosome matrix UniProt Subcellular Location entry SL-0332 maps directly to GO:0034468, places the glycosome matrix under the glycosome subcellular location, and lists glycosomal lumen, glycosomal matrix and glycosome lumen as exact synonyms.
uniprot.location:SL-0128 — Glycosome membrane UniProt Subcellular Location entry SL-0128 maps the glycosome membrane to GO:0046860.
DOI:10.1016/0014-5793(77)80476-6 Opperdoes and Borst 1977, Localization of nine glycolytic enzymes in a microbody-like organelle in Trypanosoma brucei: the glycosome, FEBS Letters.
DOI:10.1073/pnas.0806664105 Haanstra et al. 2008, Compartmentation prevents a lethal turbo-explosion of glycolysis in trypanosomes, Proceedings of the National Academy of Sciences.
DOI:10.1016/j.bbamcr.2015.09.015 Haanstra et al. 2016, Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites, Biochimica et Biophysica Acta - Molecular Cell Research.

2026-09-13T14:40:17Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-13T14:40:42Z codex · EXPANDED_RECORD — Added glycosome matrix synonyms and the UniProt SL xref, organelle-lumen parentage, glycosome parthood, Kinetoplastea and Trypanosoma scope, a glycolytic-compartmentation function, GO/UniProt/DOI evidence, a nonmechanistic lumen-topology graph, and a resolved boundary interpretation.