glycosome membrane

GO:0046860 · Membrane organelle · Membrane · Proposed

The membrane surrounding the glycosome. [GO:0046860]

Synonyms: glycosomal membrane

Part of: glycosome (GO:0020015)

Xrefs: uniprot.location:SL-0128 — Glycosome membrane

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
glycosome lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Peroxisome-related lipid bilayer that surrounds the glycosome and separates the glycosomal matrix from the kinetoplastid cytosol. `GO:0046860` GO:0046860 identifies the glycosome membrane as the membrane surrounding a glycosome. `DOI:10.1016/j.bbamcr.2015.09.015` Haanstra et al. 2016 review glycosomes as membrane-bounded specialized peroxisomes of trypanosomatid parasites.

NCBITaxon:5653 Kinetoplastea — COMMON: Glycosome membranes bound the specialized peroxisomes of kinetoplastid protists, with biogenesis and membrane import best reviewed in trypanosomatids. [DOI:10.1016/j.bbamcr.2015.09.015]

NCBITaxon:5691 Trypanosoma brucei — Kinetoplastid parasite in which PEX14-mediated glycosomal membrane import has been characterized. [DOI:10.1046/j.1432-1033.2003.03582.x]

glycosomal matrix import boundary — The glycosome membrane separates the matrix from the cytosol and hosts peroxin machinery that imports nuclear-encoded PTS-containing matrix proteins.
- DOI:10.1046/j.1432-1033.2003.03582.x Choe et al. 2003 characterized Trypanosoma brucei PEX14 as a glycosomal membrane protein that interacts with TbPEX5 during matrix-protein import.
- DOI:10.1016/j.bbamcr.2015.09.015 Haanstra et al. 2016 review conserved peroxin machinery in trypanosomatid glycosome biogenesis and maintenance.

The glycosome membrane surrounds the glycosome, encloses the matrix, and hosts peroxin machinery that imports PTS-containing enzymes.

Subject	Predicate	Object	Evidence
glycosome membrane	is part of	glycosome	`GO:0046860` GO:0046860 defines the glycosome membrane by its surrounding relation to the glycosome. `DOI:10.1016/j.bbamcr.2015.09.015` Haanstra et al. 2016 review glycosomes as membrane-bounded specialized peroxisomes.
glycosome lumen	is enclosed by	glycosome membrane	`GO:0034468` GO:0034468 defines the glycosome lumen as the volume enclosed by the glycosome membrane.
PEX14 import docking machinery	resides in	glycosome membrane	`DOI:10.1046/j.1432-1033.2003.03582.x` Choe et al. 2003 characterized Trypanosoma brucei PEX14 and its interaction with TbPEX5.
PEX14 import docking machinery	supports	glycosomal matrix protein import	`DOI:10.1046/j.1432-1033.2003.03582.x` Choe et al. 2003 linked TbPEX14 to glycosomal matrix-protein import. `DOI:10.1016/j.bbamcr.2015.09.015` Haanstra et al. 2016 review PEX import machinery as part of trypanosomatid glycosome biogenesis.

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the generic lipid constituent of the glycosome membrane. The record is exactly grounded to GO:0046860, but no glycosome-specific lipid or lipid-bilayer CURIE was curated for the membrane constituent.

GO:0046860 Gene Ontology cellular-component term for the glycosome membrane.
GO:0005778 Gene Ontology cellular-component parent term for peroxisomal membrane.
GO:0020015 Gene Ontology cellular-component term for the containing glycosome.
GO:0034468 Gene Ontology cellular-component term for the glycosome lumen bounded by the glycosome membrane.
uniprot.location:SL-0128 — Glycosome membrane UniProt Subcellular Location entry SL-0128 maps directly to GO:0046860 and lists glycosomal membrane as an exact synonym.
DOI:10.1046/j.1432-1033.2003.03582.x Choe et al. 2003, Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins, European Journal of Biochemistry.
DOI:10.1016/j.bbamcr.2015.09.015 Haanstra et al. 2016, Biogenesis, maintenance and dynamics of glycosomes in trypanosomatid parasites, Biochimica et Biophysica Acta - Molecular Cell Research.

2026-09-13T14:56:06Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-13T14:56:56Z codex · EXPANDED_RECORD — Added the UniProt SL glycosomal-membrane synonym and xref, peroxisomal-membrane parentage, glycosome parthood, a label-only lipid-bilayer component, Kinetoplastea/Trypanosoma scope, a matrix-import boundary function, GO/UniProt/DOI evidence, a nonmechanistic glycosome-membrane topology graph, and a lipid-grounding TODO.
2026-09-20T21:58:46Z codex · ADDRESSED_REVIEW — Retyped the glycosome lumen graph node as CELLULAR_LOCALIZATION.