hydrogenosomal membrane

GO:0046859 · Membrane organelle · Membrane · Proposed

The lipid bilayer surrounding a hydrogenosome. [GO:0046859]

Synonyms: hydrogenosome membrane

Part of: hydrogenosome (GO:0042566)

Xrefs: uniprot.location:SL-0144 — Hydrogenosome membrane

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
hydrogenosomal lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Mitochondrion-related lipid boundary that surrounds the hydrogenosome and separates its metabolic matrix from the cytosol. `GO:0046859` GO:0046859 identifies the hydrogenosomal membrane as the lipid bilayer surrounding a hydrogenosome. `DOI:10.1111/jeu.12922` Tachezy 2022 reviews hydrogenosomes as membrane-bounded mitochondrion-related organelles of anaerobic eukaryotes.

NCBITaxon:2759 Eukaryota — RARE: Hydrogenosomal membranes occur patchily in anaerobic microbial eukaryotes that carry hydrogenosomes as modified mitochondria. [DOI:10.1111/jeu.12922]
NCBITaxon:5722 Trichomonas vaginalis — COMMON: The parasite contains abundant hydrogenosomes whose membrane-bounded proteome and metabolism have been experimentally characterized. [DOI:10.1016/j.ijpara.2011.10.001]

NCBITaxon:5722 Trichomonas vaginalis — Parabasalid parasite in which hydrogenosomal metabolism, protein targeting, and the organelle proteome have been experimentally studied. [DOI:10.1016/j.ijpara.2011.10.001]

hydrogenosome lumen boundary — The hydrogenosomal membrane forms the lipid boundary around the internal matrix compartment that contains anaerobic energy-metabolism enzymes.
- GO:0034492 GO:0034492 defines the hydrogenosome lumen as the volume enclosed by the hydrogenosome membrane.
- GO:0046859 GO:0046859 identifies the hydrogenosomal membrane as the lipid bilayer surrounding a hydrogenosome.
- DOI:10.1111/jeu.12922 Tachezy 2022 reviews hydrogenosomes as membrane-bounded mitochondrion-related organelles.

The hydrogenosomal membrane surrounds the organelle and encloses the matrix compartment used for anaerobic ATP and molecular-hydrogen production.

Subject	Predicate	Object	Evidence
hydrogenosomal membrane	is part of	hydrogenosome	`GO:0046859` GO:0046859 identifies the hydrogenosomal membrane as surrounding a hydrogenosome. `uniprot.location:SL-0144` — Hydrogenosome membrane UniProt SL-0144 places the hydrogenosome membrane under the hydrogenosome subcellular location.
hydrogenosome lumen	is enclosed by	hydrogenosomal membrane	`GO:0034492` GO:0034492 defines the hydrogenosome lumen as the volume enclosed by the hydrogenosome membrane. `GO:0046859` GO:0046859 identifies the hydrogenosomal membrane as the lipid bilayer surrounding a hydrogenosome. `DOI:10.1111/jeu.12922` Tachezy 2022 reviews hydrogenosomes as membrane-bounded mitochondrion-related organelles.

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the generic lipid constituent of the hydrogenosomal membrane. The record is exactly grounded to GO:0046859, but no hydrogenosome-specific lipid or lipid-bilayer CURIE was curated for the membrane constituent.

GO:0046859 Gene Ontology cellular-component term for the hydrogenosomal membrane.
GO:0016020 Gene Ontology cellular-component parent term for membrane.
GO:0042566 Gene Ontology cellular-component term for the containing hydrogenosome.
GO:0034492 Gene Ontology cellular-component term for the hydrogenosome lumen bounded by the hydrogenosomal membrane.
uniprot.location:SL-0144 — Hydrogenosome membrane UniProt Subcellular Location entry SL-0144 maps to GO:0046859, places the membrane under the hydrogenosome subcellular location, and lists hydrogenosome membrane as the entry name.
DOI:10.1016/j.ijpara.2011.10.001 Schneider et al. 2011, The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes, International Journal for Parasitology.
DOI:10.1111/jeu.12922 Tachezy 2022, Hydrogenosomes and mitosomes: Mitochondria of anaerobic eukaryotes, Journal of Eukaryotic Microbiology.

2026-09-13T15:25:24Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-13T15:25:51Z codex · EXPANDED_RECORD — Added the UniProt SL hydrogenosome-membrane synonym and xref, membrane parentage, hydrogenosome parthood, a label-only lipid-bilayer component, Eukaryota/Trichomonas scope, a lumen-boundary function, GO/UniProt/DOI evidence, a nonmechanistic hydrogenosomal-membrane topology graph, and a lipid-grounding TODO.