hydrogenosome lumen

GO:0034492 · Membrane organelle · Subcellular region · Proposed

The volume enclosed by the hydrogenosome membrane. [GO:0034492]

Synonyms: hydrogenosomal lumen

Part of: hydrogenosome (GO:0042566)

Xrefs: uniprot.location:SL-0335 — Hydrogenosome lumen

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Taxonomic distribution

• NCBITaxon:2759 Eukaryota — RARE: Hydrogenosome lumina occur in the hydrogenosome-bearing subset of anaerobic microbial eukaryotes. [DOI:10.1111/jeu.12922]
• NCBITaxon:5722 Trichomonas vaginalis — COMMON: Trichomonas vaginalis has hydrogenosome matrix compartments whose imported enzymes support pyruvate metabolism, hydrogen production, and iron-sulfur cluster assembly. [DOI:10.1016/j.ijpara.2011.10.001]

Canonical examples

• NCBITaxon:5722 Trichomonas vaginalis — Parabasalid parasite whose hydrogenosome lumen contains experimentally characterized energy-metabolism and ISC-assembly proteins. [DOI:10.1073/pnas.0401319101]

Functions

• hydrogenosome lumen metabolism — The hydrogenosome lumen is the matrix compartment that contains enzymes for anaerobic ATP and molecular hydrogen production and mitochondrial-type iron-sulfur cluster assembly.
  • DOI:10.1016/j.ijpara.2011.10.001 Schneider et al. 2011 identified the Trichomonas hydrogenosome proteome, including energy-metabolism proteins.
  • DOI:10.1073/pnas.0401319101 Sutak et al. 2004 localized mitochondrial-type iron-sulfur center assembly to Trichomonas vaginalis hydrogenosomes.

Mechanism graphs

Hydrogenosome lumen topology (FUNCTION)

The hydrogenosome lumen is the internal hydrogenosome compartment enclosed by the hydrogenosomal membrane.

Discussions

• INTERPRETATION (RESOLVED): Keep the hydrogenosomal membrane as the boundary of the hydrogenosome lumen rather than as a lumen component. GO:0034492 denotes the volume enclosed by the hydrogenosome membrane, whereas GO:0046859 denotes the lipid bilayer surrounding a hydrogenosome.

Evidence

• GO:0034492 Gene Ontology cellular-component term for hydrogenosome lumen.
• GO:0043233 Gene Ontology cellular-component term for organelle lumen, the broader organelle-enclosed compartment parent.
• GO:0042566 Gene Ontology cellular-component term for hydrogenosome, the containing organelle.
• GO:0046859 Gene Ontology cellular-component term for the hydrogenosomal membrane that encloses the lumen.
• uniprot.location:SL-0335 — Hydrogenosome lumen UniProt Subcellular Location entry SL-0335 maps directly to GO:0034492, places the hydrogenosome lumen under the hydrogenosome, and lists hydrogenosomal lumen as an exact synonym.
• uniprot.location:SL-0144 — Hydrogenosome membrane UniProt Subcellular Location entry SL-0144 maps the hydrogenosome membrane to GO:0046859.
• PMID:4750424 Lindmark and Muller 1973 isolated the hydrogen-producing organelle of Tritrichomonas foetus and linked it to pyruvate metabolism.
• DOI:10.1016/j.ijpara.2011.10.001 Schneider et al. 2011, The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes, International Journal for Parasitology.
• DOI:10.1073/pnas.0401319101 Sutak et al. 2004, Mitochondrial-type assembly of iron-sulfur centers in the hydrogenosomes of the amitochondriate eukaryote Trichomonas vaginalis, Proceedings of the National Academy of Sciences.
• DOI:10.1111/jeu.12922 Tachezy 2022, Hydrogenosomes and mitosomes: Mitochondria of anaerobic eukaryotes, Journal of Eukaryotic Microbiology.

Curation history

• 2026-09-13T14:05:22Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
• 2026-09-13T14:06:08Z codex · EXPANDED_RECORD — Added the hydrogenosomal lumen synonym and UniProt SL xref, organelle-lumen parentage, hydrogenosome parthood, Eukaryota and Trichomonas scope, Trichomonas as a canonical example, a matrix-metabolism function, GO/UniProt/PMID/DOI evidence, a nonmechanistic lumen-topology graph, and a resolved boundary interpretation.

Source: data/structures/membrane_organelle/hydrogenosome_lumen.yaml