magnetosome lumen

GO:0110145 · Membrane organelle · Subcellular region · Proposed

The volume enclosed by the magnetosome membrane. [GO:0110145]

Part of: magnetosome (GO:0110143)

Xrefs: uniprot.location:SL-0511 — Magnetosome lumen

Taxonomic distribution

NCBITaxon:2 Bacteria — RARE: Magnetosome lumina occur inside magnetosome vesicles in magnetotactic bacterial lineages rather than broadly across Bacteria. [DOI:10.1038/nrmicro.2016.99]
NCBITaxon:28211 Alphaproteobacteria — VARIABLE: Alphaproteobacterial magnetotactic model strains build magnetosome vesicles with membrane-enclosed mineralization lumina, but magnetotaxis is confined to particular lineages. [DOI:10.1038/nrmicro.2016.99]

NCBITaxon:431944 Magnetospirillum gryphiswaldense MSR-1 — Alphaproteobacterial model used for biochemical and proteomic analysis of isolated magnetosome membranes and for genetic analysis of magnetosome vesicle assembly. [PMID:14766587]

magnetosome lumen biomineralization — The magnetosome lumen is the membrane-enclosed compartment in which imported iron is mineralized into a magnetic iron-mineral crystal.
- DOI:10.1038/nrmicro.2016.99 Uebe and Schuler 2016 review magnetosome vesicles as the compartments in which iron is accumulated and biomineralized as magnetite or greigite.
- PMID:22007638 Uebe et al. 2011 linked MamB and MamM to magnetite biomineralization and magnetosome membrane assembly in Magnetospirillum gryphiswaldense.

The magnetosome lumen is the internal magnetosome compartment enclosed by the magnetosome membrane.

Subject	Predicate	Object	Evidence
magnetosome lumen	is part of	magnetosome	`GO:0110145` GO:0110145 identifies the magnetosome lumen cellular component. `uniprot.location:SL-0511` — Magnetosome lumen UniProt SL-0511 places the magnetosome lumen under the magnetosome subcellular location. `GO:0110143` GO:0110143 identifies the containing magnetosome.
magnetosome membrane	encloses	magnetosome lumen	`GO:0110145` GO:0110145 identifies the lumen under the magnetosome subcellular location. `GO:0110146` GO:0110146 identifies the magnetosome membrane that surrounds the organelle. `uniprot.location:SL-0512` — Magnetosome membrane UniProt SL-0512 maps the magnetosome membrane to GO:0110146.
magnetosome biomineralization	occurs in	magnetosome lumen	`DOI:10.1038/nrmicro.2016.99` Uebe and Schuler 2016 review magnetosome vesicles as the site of magnetite or greigite biomineralization.

INTERPRETATION (RESOLVED): Keep the magnetosome membrane as the boundary of the magnetosome lumen rather than as a lumen component. GO:0110145 denotes the magnetosome lumen, whereas GO:0110146 denotes the lipid bilayer surrounding a magnetosome.

GO:0110145 Gene Ontology cellular-component term for the magnetosome lumen.
GO:0043233 Gene Ontology cellular-component term for organelle lumen, the broader organelle-enclosed compartment parent.
GO:0110143 Gene Ontology cellular-component term for the containing magnetosome.
GO:0110146 Gene Ontology cellular-component term for the magnetosome membrane that encloses the lumen.
uniprot.location:SL-0511 — Magnetosome lumen UniProt Subcellular Location entry SL-0511 maps directly to GO:0110145 and places the magnetosome lumen under the magnetosome subcellular location.
uniprot.location:SL-0512 — Magnetosome membrane UniProt Subcellular Location entry SL-0512 maps the magnetosome membrane to GO:0110146.
DOI:10.1038/nrmicro.2016.99 Uebe R and Schuler D 2016, Magnetosome biogenesis in magnetotactic bacteria, Nature Reviews Microbiology.
PMID:14766587 Grunberg et al. 2004, Biochemical and proteomic analysis of the magnetosome membrane in Magnetospirillum gryphiswaldense, Applied and Environmental Microbiology.
PMID:22007638 Uebe et al. 2011, The cation diffusion facilitator proteins MamB and MamM of Magnetospirillum gryphiswaldense have distinct and complex functions, and are involved in magnetite biomineralization and magnetosome membrane assembly, Molecular Microbiology.

2026-09-13T16:22:48Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-13T16:23:16Z codex · EXPANDED_RECORD — Added the UniProt SL xref, organelle-lumen parentage, magnetosome parthood, bacterial/Alphaproteobacteria scope, an MSR-1 example, a biomineralization function, GO/UniProt/DOI/PMID evidence, a nonmechanistic lumen-topology graph, and a resolved boundary interpretation.