microneme lumen

GO:0034494 · Membrane organelle · Subcellular region · Proposed

The volume enclosed by the microneme membrane. [GO:0034494]

Part of: microneme (GO:0020009)

Taxonomic distribution

NCBITaxon:5794 Apicomplexa — COMMON: Microneme lumina are the internal secretory compartments of apicomplexan micronemes, which store adhesins before regulated microneme discharge during motility and invasion. [DOI:10.1007/978-0-387-78267-6_2]

NCBITaxon:5811 Toxoplasma gondii — Apicomplexan model whose microneme lumen stores adhesin cargo that is released during regulated microneme exocytosis. [PMID:9208224]

microneme secretory cargo storage — The microneme lumen stores adhesin cargo before regulated microneme exocytosis.
- DOI:10.1007/978-0-387-78267-6_2 Carruthers and Tomley 2008 review apicomplexan microneme adhesins and their roles in motility and invasion.
- PMID:9208224 Carruthers and Sibley 1997 showed that microneme secretion accompanies the first phase of Toxoplasma host-cell invasion.

The microneme lumen is the internal microneme compartment enclosed by the microneme membrane.

Subject	Predicate	Object	Evidence
microneme lumen	is part of	microneme	`GO:0034494` GO:0034494 identifies the microneme lumen cellular component. `GO:0020009` GO:0020009 identifies the containing microneme organelle. `DOI:10.1111/cmi.13018` Dubois and Soldati-Favre 2019 review microneme biogenesis and exocytosis.
microneme membrane	encloses	microneme lumen	`GO:0034494` GO:0034494 defines the microneme lumen as the volume enclosed by the microneme membrane. `GO:0033163` GO:0033163 identifies the lipid bilayer surrounding a microneme.

INTERPRETATION (RESOLVED): Keep the microneme membrane as the boundary of the microneme lumen rather than as a lumen component. GO:0034494 denotes the volume enclosed by the microneme membrane, whereas GO:0033163 denotes the lipid bilayer surrounding a microneme.

GO:0034494 Gene Ontology cellular-component term for the microneme lumen.
GO:0043233 Gene Ontology cellular-component term for organelle lumen, the broader class of organelle-enclosed compartments.
GO:0033163 Gene Ontology cellular-component term for the microneme membrane that encloses the microneme lumen.
GO:0020009 Gene Ontology cellular-component term for the microneme, the organelle that contains this lumen.
DOI:10.1111/cmi.13018 Dubois and Soldati-Favre 2019, Biogenesis and secretion of micronemes in Toxoplasma gondii, Cellular Microbiology.
DOI:10.1007/978-0-387-78267-6_2 Carruthers and Tomley 2008, Microneme proteins in apicomplexans, Subcellular Biochemistry.
PMID:9208224 Carruthers and Sibley 1997, Sequential protein secretion from three distinct organelles of Toxoplasma gondii accompanies invasion of human fibroblasts, European Journal of Cell Biology.

2026-09-13T13:12:04Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-13T13:12:48Z codex · EXPANDED_RECORD — Added organelle-lumen parentage, microneme parthood, Apicomplexa and Toxoplasma gondii scope, a cargo-storage function, GO/DOI/PMID evidence, a nonmechanistic microneme-lumen topology graph, and a resolved boundary interpretation.