mitosome intermembrane space

cellstructuremech:mitosome_intermembrane_space · Membrane organelle · Subcellular region · Proposed

The mitosomal intermembrane space is the space between inner and outer mitosomal membranes. [uniprot.location:SL-0440 — Mitosome intermembrane space]

Synonyms: mitosomal intermembrane space; mitosomal periplasm; mitosomal periplasmic space

Part of: mitosome envelope (cellstructuremech:mitosome_envelope)

Xrefs: uniprot.location:SL-0440 — Mitosome intermembrane space

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Taxonomic distribution

NCBITaxon:2759 Eukaryota — RARE: Mitosome intermembrane spaces occur in the patchy anaerobic or microaerophilic microbial eukaryotes that retain double-membrane mitochondrion-related mitosomes. [DOI:10.1111/jeu.12922]
NCBITaxon:5759 Entamoeba histolytica — COMMON: The Entamoeba mitochondrion-related mitosome was identified as a double-membrane organelle. [DOI:10.1046/j.1365-2958.1999.01414.x]

Canonical examples

NCBITaxon:5759 Entamoeba histolytica — Amoebozoan parasite in which a double-membrane mitochondrion-related mitosome was initially described. [DOI:10.1046/j.1365-2958.1999.01414.x]

Mechanism graphs

Mitosome intermembrane-space topology (FUNCTION)

The mitosome intermembrane space lies between the inner and outer mitosomal membranes of the mitosome envelope.

Subject	Predicate	Object	Evidence
mitosome intermembrane space	is part of	mitosome envelope	`uniprot.location:SL-0438` — Mitosome envelope UniProt SL-0438 defines the mitosome envelope as comprising the inner and outer mitosomal membranes plus the intermembrane space. `uniprot.location:SL-0440` — Mitosome intermembrane space UniProt SL-0440 places the mitosome intermembrane space under the mitosome envelope location.
mitosome outer membrane	delimits	mitosome intermembrane space	`uniprot.location:SL-0440` — Mitosome intermembrane space UniProt SL-0440 defines the mitosome intermembrane space as the space between the inner and outer mitosomal membranes. `uniprot.location:SL-0443` — Mitosome outer membrane UniProt SL-0443 defines the mitosome outer membrane by its orientation toward the cytoplasm.
mitosome inner membrane	delimits	mitosome intermembrane space	`uniprot.location:SL-0440` — Mitosome intermembrane space UniProt SL-0440 defines the mitosome intermembrane space as the space between the inner and outer mitosomal membranes. `uniprot.location:SL-0439` — Mitosome inner membrane UniProt SL-0439 defines the mitosome inner membrane by its position between the matrix and the intermembrane space.

Evidence

uniprot.location:SL-0440 — Mitosome intermembrane space UniProt Subcellular Location entry SL-0440 identifies the mitosome intermembrane space, lists mitosomal intermembrane space, mitosomal periplasm, and mitosomal periplasmic space as exact synonyms, and places it under the mitosome envelope location.
uniprot.location:SL-0438 — Mitosome envelope UniProt Subcellular Location entry SL-0438 identifies the mitosome envelope as including the intermembrane space.
uniprot.location:SL-0439 — Mitosome inner membrane UniProt Subcellular Location entry SL-0439 identifies the mitosome inner membrane as separating the mitosome matrix from the intermembrane space.
uniprot.location:SL-0443 — Mitosome outer membrane UniProt Subcellular Location entry SL-0443 identifies the outer boundary of the mitosome envelope.
DOI:10.1046/j.1365-2958.1999.01414.x Tovar et al. 1999, The mitosome, a novel organelle related to mitochondria in the amitochondrial parasite Entamoeba histolytica, Molecular Microbiology.
DOI:10.1111/jeu.12922 Tachezy 2022, Hydrogenosomes and mitosomes: Mitochondria of anaerobic eukaryotes, Journal of Eukaryotic Microbiology.

Curation history

2026-09-13T19:58:57Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-13T19:59:51Z codex · EXPANDED_RECORD — Added UniProt SL mitosomal-intermembrane-space synonyms and xref, mitosome-envelope parthood, rare anaerobic eukaryote and Entamoeba scope, UniProt/DOI evidence, and a nonmechanistic intermembrane-space topology graph.

Source: data/structures/membrane_organelle/mitosome_intermembrane_space.yaml