multivesicular body lumen

cellstructuremech:multivesicular_body_lumen · Membrane organelle · Subcellular region · Proposed

The multivesicular body compartment bounded by the multivesicular body membrane. [uniprot.location:SL-0340 — Multivesicular body lumen]

Synonyms: Corpuscula multivesicularis lumen; ECV lumen; Endosomal carrier vesicle lumen; Multivesicular bodies lumen; MVB lumen

Part of: multivesicular body (GO:0005771)

Xrefs: uniprot.location:SL-0340 — Multivesicular body lumen

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast forms multivesicular bodies with lumens that receive intraluminal vesicles during ESCRT-dependent cargo sorting. [PMID:11511343]

NCBITaxon:4932 Saccharomyces cerevisiae — Genetic model for ESCRT-dependent formation of intraluminal vesicles inside multivesicular bodies. [PMID:12194857]

multivesicular body sorting pathway GO:0071985 — The multivesicular body lumen receives intraluminal vesicles and their endosomal membrane cargo during ESCRT-dependent multivesicular body sorting.
- GO:0071985 GO:0071985 denotes the multivesicular body sorting pathway that targets ubiquitylated transmembrane proteins into luminal vesicles.
- PMID:11511343 Katzmann, Babst and Emr 2001 identified ESCRT-I as a conserved yeast endosomal protein-sorting complex needed for MVB cargo sorting.

The multivesicular body membrane bounds the lumen that contains intraluminal vesicles inside a multivesicular body.

Subject	Predicate	Object	Evidence
multivesicular body lumen	is a	endosome lumen	`uniprot.location:SL-0340` — Multivesicular body lumen UniProt SL-0340 places the multivesicular body lumen under endosome lumen. `GO:0031904` GO:0031904 identifies the endosome lumen class.
multivesicular body lumen	is part of	multivesicular body	`uniprot.location:SL-0340` — Multivesicular body lumen UniProt SL-0340 names the multivesicular body as the parent compartment of this lumen.
multivesicular body membrane	bounds	multivesicular body lumen	`uniprot.location:SL-0340` — Multivesicular body lumen UniProt SL-0340 defines the lumen as the compartment bounded by the multivesicular body membrane. `GO:0032585` GO:0032585 identifies the multivesicular body membrane.
multivesicular body intraluminal vesicle	is contained in	multivesicular body lumen	`GO:0005771` GO:0005771 defines the multivesicular body by internal vesicles formed from invagination of the limiting endosomal membrane. `uniprot.location:SL-0340` — Multivesicular body lumen UniProt SL-0340 identifies the multivesicular body lumen.

INTERPRETATION (RESOLVED): Represent the multivesicular body membrane as the boundary of the lumen rather than as a lumen component. UniProt SL-0340 denotes the MVB compartment bounded by the multivesicular body membrane, whereas GO:0032585 denotes the surrounding lipid bilayer.

uniprot.location:SL-0340 — Multivesicular body lumen UniProt Subcellular Location entry SL-0340 identifies the multivesicular body lumen, lists MVB lumen synonyms, and places the lumen under endosome lumen and multivesicular body.
GO:0031904 Gene Ontology cellular-component term for the broader endosome lumen class.
GO:0005771 Gene Ontology cellular-component term for the containing multivesicular body.
GO:0032585 Gene Ontology cellular-component term for the multivesicular body membrane that bounds this lumen.
GO:0071985 Gene Ontology biological-process term for the multivesicular body sorting pathway.
PMID:11511343 Katzmann, Babst and Emr 2001, Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I, Cell.
PMID:12194857 Babst, Katzmann, Estepa-Sabal, Meerloo and Emr 2002, Escrt-III, Developmental Cell.
DOI:10.1016/j.devcel.2011.05.015 Henne, Buchkovich and Emr 2011, The ESCRT Pathway, Developmental Cell.

2026-09-15T03:12:06Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-15T03:13:01Z codex · EXPANDED_RECORD — Added UniProt SL-0340 synonymy, endosome-lumen parentage, multivesicular-body parthood, budding-yeast scope, GO/UniProt/DOI evidence, an MVB sorting function, a nonmechanistic MVB lumen topology graph, and a resolved lumen-boundary interpretation.
2026-09-21T08:41:49Z codex · REPLACED_UNREADABLE_EVIDENCE — Resolved #1224 by routing Katzmann, Babst and Emr 2001 ESCRT-I evidence through reachable PMID:11511343 instead of the unreadable Cell DOI.
2026-09-21T09:03:20Z codex · REPLACED_UNREADABLE_EVIDENCE — Resolved #1225 by routing Babst et al. 2002 ESCRT-III evidence through reachable PMID:12194857 instead of the unreadable Developmental Cell DOI.
2026-09-23T08:14:15Z codex · LINKED_INTRALUMINAL_VESICLE_RECORD — Grounded the multivesicular-body intraluminal vesicle graph node to cellstructuremech:multivesicular_body_intraluminal_vesicle.