parasitophorous vacuole lumen

cellstructuremech:parasitophorous_vacuole_lumen · Membrane organelle · Subcellular region · Proposed

The parasitophorous vacuole compartment bounded by the membrane of the parasitophorous vacuole. [uniprot.location:SL-0341 — Parasitophorous vacuole lumen]

Synonyms: parasitophorous vacuolar lumen

Part of: parasitophorous vacuole (cellstructuremech:parasitophorous_vacuole)

Xrefs: uniprot.location:SL-0341 — Parasitophorous vacuole lumen

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Taxonomic distribution

NCBITaxon:5794 Apicomplexa — COMMON: UniProt places the parasitophorous vacuole lumen under the parasitophorous vacuole location, whose definition scopes the vacuole to the host-cell compartment in which most apicomplexan parasites reside and develop. [uniprot.location:SL-0194 — Parasitophorous vacuole]

Mechanism graphs

Parasitophorous vacuole lumen topology (FUNCTION)

The parasitophorous vacuole lumen is the internal compartment of the parasitophorous vacuole.

Subject	Predicate	Object	Evidence
parasitophorous vacuole lumen	is part of	parasitophorous vacuole	`uniprot.location:SL-0341` — Parasitophorous vacuole lumen UniProt SL-0341 places the parasitophorous vacuole lumen under the parasitophorous vacuole. `uniprot.location:SL-0194` — Parasitophorous vacuole UniProt SL-0194 identifies the parasitophorous vacuole containing the lumen.

Discussions

INTERPRETATION (RESOLVED): Model GO:0020004 as a broad parent rather than as the exact parasitophorous vacuole lumen identity. GO:0020004 names the symbiont-containing vacuolar space class, whereas UniProt SL-0341 names the narrower lumen of the Apicomplexa-scoped parasitophorous vacuole.

Evidence

uniprot.location:SL-0341 — Parasitophorous vacuole lumen UniProt Subcellular Location entry SL-0341 identifies the parasitophorous vacuole lumen, lists parasitophorous vacuolar lumen as an exact synonym, and places the lumen under the parasitophorous vacuole location.
GO:0020004 Gene Ontology cellular-component term for the broader symbiont-containing vacuolar space class.
uniprot.location:SL-0194 — Parasitophorous vacuole UniProt Subcellular Location entry SL-0194 identifies the Apicomplexa-scoped parasitophorous vacuole containing the parasitophorous vacuole lumen.

Curation history

2026-09-13T18:32:24Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-13T18:33:04Z codex · EXPANDED_RECORD — Added the UniProt SL synonym and xref, symbiont-containing-vacuolar-space parentage, parasitophorous-vacuole parthood, Apicomplexa distribution, lumen-residence function, GO/UniProt evidence, a nonmechanistic topology graph, and a resolved GO scope discussion.
2026-09-13T18:41:39Z codex · ADDRESSED_REVIEW — Resolved #824 and #825 by removing the topological restatement from functions and narrowing the topology graph scope note so it no longer implies PVM-remodeling mechanisms are curated on the containing vacuole.

Source: data/structures/membrane_organelle/parasitophorous_vacuole_lumen.yaml