parasitophorous vacuole membrane

cellstructuremech:parasitophorous_vacuole_membrane · Membrane organelle · Membrane · Proposed

The membrane surrounding the parasitophorous vacuole. [uniprot.location:SL-0193 — Parasitophorous vacuole membrane]

Synonyms: parasitophorous vacuolar membrane

Part of: parasitophorous vacuole (cellstructuremech:parasitophorous_vacuole)

Xrefs: uniprot.location:SL-0193 — Parasitophorous vacuole membrane

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
parasitophorous vacuole membrane lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Generic lipid-bilayer constituent that surrounds the parasitophorous vacuole and separates it from the host cytosol. `uniprot.location:SL-0193` — Parasitophorous vacuole membrane UniProt Subcellular Location SL-0193 identifies the parasitophorous vacuole membrane as the membrane surrounding the parasitophorous vacuole. `DOI:10.1242/jcs.111.11.1467` Lingelbach and Joiner 1998 review the parasitophorous vacuolar membrane surrounding intracellular Plasmodium and Toxoplasma parasites.

NCBITaxon:5794 Apicomplexa — COMMON: UniProt places the parasitophorous vacuole membrane under the parasitophorous vacuole location, whose definition scopes the vacuole to host-cell compartments formed by most apicomplexan parasites. [uniprot.location:SL-0194 — Parasitophorous vacuole]

NCBITaxon:5811 Toxoplasma gondii — Apicomplexan model whose parasitophorous vacuole membrane is reviewed as a parasite-remodeled host-parasite interface. [DOI:10.1016/j.pt.2017.02.007]
NCBITaxon:5833 Plasmodium falciparum — Human malaria parasite whose intraerythrocytic PVM was surveyed by proximity labeling to identify PVM-associated proteins. [DOI:10.1128/mSphere.00522-17]

The parasitophorous vacuole membrane surrounds the parasitophorous vacuole.

Subject	Predicate	Object	Evidence
parasitophorous vacuole membrane	bounds	parasitophorous vacuole	`uniprot.location:SL-0193` — Parasitophorous vacuole membrane UniProt SL-0193 identifies the PVM as the membrane surrounding the parasitophorous vacuole. `uniprot.location:SL-0194` — Parasitophorous vacuole UniProt SL-0194 defines the PV as a host-cell vacuole enclosed by the PVM.

INTERPRETATION (RESOLVED): Model GO:0020005 as a broad parent rather than as the exact Apicomplexa-scoped parasitophorous vacuole membrane identity. GO:0020005 names the broad symbiont-containing vacuole membrane class, whereas UniProt SL-0193 names the narrower membrane surrounding an Apicomplexa-scoped parasitophorous vacuole.
CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the generic lipid constituent of the PVM. UniProt SL-0193 identifies the whole PVM, but no exact Apicomplexa-scoped lipid or lipid-bilayer CURIE was curated for the generic bilayer constituent.

uniprot.location:SL-0193 — Parasitophorous vacuole membrane UniProt Subcellular Location entry SL-0193 identifies the parasitophorous vacuole membrane, lists parasitophorous vacuolar membrane as an exact synonym, and maps the term to the broader GO:0020005 symbiont-containing vacuole membrane class.
GO:0020005 Gene Ontology cellular-component term for the broader symbiont-containing vacuole membrane class.
uniprot.location:SL-0194 — Parasitophorous vacuole UniProt Subcellular Location entry SL-0194 identifies the containing parasitophorous vacuole.
DOI:10.1242/jcs.111.11.1467 Lingelbach and Joiner 1998, The parasitophorous vacuole membrane surrounding Plasmodium and Toxoplasma: an unusual compartment in infected cells, Journal of Cell Science.
DOI:10.1016/j.pt.2017.02.007 Clough and Frickel 2017, The Toxoplasma Parasitophorous Vacuole: An Evolving Host-Parasite Frontier, Trends in Parasitology.
DOI:10.1128/mSphere.00522-17 Schnider et al. 2018, BioID Reveals Novel Proteins of the Plasmodium Parasitophorous Vacuole Membrane, mSphere.

2026-09-13T18:53:10Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-13T18:53:40Z codex · EXPANDED_RECORD — Added the UniProt SL synonym and xref, symbiont-containing-vacuole-membrane parentage, parasitophorous-vacuole parthood, a label-only PVM lipid-bilayer component, Apicomplexa distribution, Toxoplasma and Plasmodium examples, GO/UniProt/DOI evidence, a nonmechanistic topology graph, and GO and lipid-bilayer grounding discussions.