plastid intermembrane space

GO:0009529 · Membrane organelle · Subcellular region · Proposed

The region between the inner and outer lipid bilayers of the plastid envelope. [GO:0009529]

Synonyms: Plastidic intermembrane space

Part of: plastid envelope (GO:0009526)

Xrefs: uniprot.location:SL-0212 — Plastid intermembrane space

Taxonomic distribution

NCBITaxon:33090 Viridiplantae — COMMON: Green algae and land plants carry primary plastids whose double envelopes enclose an intermembrane space between the inner and outer plastid membranes. [DOI:10.1098/rstb.2009.0103]
NCBITaxon:3055 Chlamydomonas reinhardtii — COMMON: The Chlamydomonas reinhardtii chloroplast envelope has an intermembrane space across which the TOC-TIC import supercomplex spans the outer and inner membranes. [DOI:10.1016/j.cell.2022.10.030]

NCBITaxon:3055 Chlamydomonas reinhardtii — Green-algal model used for structural analysis of a TOC-TIC supercomplex spanning the chloroplast outer and inner envelope membranes. [DOI:10.1016/j.cell.2022.10.030]

The plastid intermembrane space lies between the inner and outer plastid envelope membranes.

Subject	Predicate	Object	Evidence
plastid intermembrane space	is part of	plastid envelope	`GO:0009529` GO:0009529 defines this region by its position between the inner and outer plastid-envelope lipid bilayers. `uniprot.location:SL-0212` — Plastid intermembrane space UniProt SL-0212 lists Plastid envelope as the host parent for the plastid intermembrane space.
plastid outer membrane	delimits	plastid intermembrane space	`GO:0009529` GO:0009529 defines the plastid intermembrane space as the region between the inner and outer plastid envelope lipid bilayers. `GO:0009527` GO:0009527 defines the plastid outer membrane as the cytoplasm-facing lipid bilayer of the plastid envelope.
plastid inner membrane	delimits	plastid intermembrane space	`GO:0009529` GO:0009529 defines the plastid intermembrane space as the region between the inner and outer plastid envelope lipid bilayers. `uniprot.location:SL-0211` — Plastid inner membrane UniProt SL-0211 describes the plastid inner membrane as separating the plastid stroma from the intermembrane space.

GO:0009529 Gene Ontology cellular-component term for plastid intermembrane space.
GO:0009526 Gene Ontology cellular-component term for the plastid envelope that contains the intermembrane space.
GO:0009527 Gene Ontology cellular-component term for the outer plastid membrane that delimits this space.
GO:0009528 Gene Ontology cellular-component term for the inner plastid membrane that delimits this space.
uniprot.location:SL-0212 — Plastid intermembrane space UniProt Subcellular Location entry SL-0212 maps Plastid intermembrane space to GO:0009529 and lists Plastid envelope as its host parent.
uniprot.location:SL-0211 — Plastid inner membrane UniProt Subcellular Location entry SL-0211 maps Plastid inner membrane to GO:0009528 and describes it as separating the plastid stroma from the intermembrane space.
DOI:10.1098/rstb.2009.0103 Keeling 2010, The endosymbiotic origin, diversification and fate of plastids, Philosophical Transactions of the Royal Society B.
DOI:10.1016/j.cell.2022.10.030 Jin et al. 2022, Structure of a TOC-TIC supercomplex spanning two chloroplast envelope membranes, Cell.

2026-09-13T21:38:15Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-13T21:38:59Z codex · EXPANDED_RECORD — Added the UniProt SL-0212 xref and exact synonym, plastid-envelope parthood, Viridiplantae and Chlamydomonas scope, and a nonmechanistic envelope topology graph.