recycling endosome lumen

GO:0034777 · Membrane organelle · Subcellular region · Proposed

The volume enclosed by the membranes of a recycling endosome. [GO:0034777]

Synonyms: recycling endosomal lumen

Part of: recycling endosome (GO:0055037)

Xrefs: uniprot.location:SL-0345 — Recycling endosome lumen

Taxonomic distribution

NCBITaxon:5691 Trypanosoma brucei — VARIABLE: Trypanosoma brucei bloodstream and procyclic cells contain TbRAB11-positive membrane-enclosed endosomal recycling compartments. [PMID:11683389]

NCBITaxon:5691 Trypanosoma brucei — Kinetoplastid parasite whose TbRAB11-positive endosomal recycling compartments instantiate lumens enclosed by recycling endosome membranes. [PMID:11683389]

recycling endosome lumen compartmentalization — The recycling endosome lumen is the bounded volume enclosed by recycling-endosome membranes inside a plasma-membrane recycling compartment.
- GO:0034777 GO:0034777 defines the recycling endosome lumen as the volume enclosed by recycling-endosome membranes.
- GO:0055038 GO:0055038 identifies the surrounding recycling endosome membrane.

The recycling endosome lumen is a specialized endosome lumen enclosed by a recycling endosome membrane.

Subject	Predicate	Object	Evidence
recycling endosome lumen	is a	endosome lumen	`uniprot.location:SL-0345` — Recycling endosome lumen UniProt SL-0345 places the recycling endosome lumen under endosome lumen. `GO:0031904` GO:0031904 identifies the broader endosome lumen class.
recycling endosome lumen	is part of	recycling endosome	`GO:0034777` GO:0034777 defines the recycling endosome lumen as the volume enclosed by recycling-endosome membranes.
recycling endosome membrane	bounds	recycling endosome lumen	`GO:0055038` GO:0055038 identifies the recycling endosome membrane. `GO:0034777` GO:0034777 defines the recycling endosome lumen by enclosure within recycling-endosome membranes.

INTERPRETATION (RESOLVED): Represent the recycling endosome membrane as the boundary of the recycling endosome lumen rather than as a lumen component. GO:0034777 denotes the volume enclosed by the recycling endosome membrane, whereas GO:0055038 denotes the surrounding lipid bilayer.

GO:0034777 Gene Ontology cellular-component term for the recycling endosome lumen.
GO:0031904 Gene Ontology cellular-component parent term for endosome lumen.
GO:0055037 Gene Ontology cellular-component term for the containing recycling endosome.
GO:0055038 Gene Ontology cellular-component term for the recycling endosome membrane that bounds the lumen.
uniprot.location:SL-0345 — Recycling endosome lumen UniProt Subcellular Location entry SL-0345 maps Recycling endosome lumen to GO:0034777 and places it under Endosome lumen and Recycling endosome.
PMID:11683389 Jeffries, Morgan and Field 2001, A developmentally regulated rab11 homologue in Trypanosoma brucei is involved in recycling processes, Journal of Cell Science.

2026-09-22T20:44:06Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-22T20:45:02Z codex · EXPANDED_RECORD — Added endosome-lumen parentage, recycling-endosome parthood, a recycling endosomal lumen synonym, UniProt SL-0345 xref, Trypanosoma brucei scope, a cargo-routing function, GO/UniProt/PubMed evidence, a nonmechanistic lumen-topology graph, and a resolved lumen-boundary interpretation.
2026-09-22T20:57:52Z codex · ADDRESSED_PR_REVIEW — Addressed PR #1321 review issues #1322 and #1323 by renaming the lumen function from cargo routing to lumen compartmentalization and rewriting the T. brucei notes so transferrin receptor is not modeled as lumenal cargo.