reservosome lumen

GO:0106124 · Membrane organelle · Subcellular region · Proposed

The volume enclosed by the membranes of a reservosome. [GO:0106124]

Part of: reservosome (cellstructuremech:reservosome)

Taxonomic distribution

NCBITaxon:5693 Trypanosoma cruzi — VARIABLE: Reservosome lumens occur in reservosomes of T. cruzi epimastigotes and are absent from amastigote and trypomastigote life-cycle forms that lack reservosomes. [DOI:10.1017/S0031182004005797]

NCBITaxon:5693 Trypanosoma cruzi — Kinetoplastid parasite whose epimastigote reservosomes were analyzed by thin-section, uranyl-acetate, and freeze-fracture electron microscopy to resolve complex internal membrane, vesicle, and lipid-inclusion architecture. [DOI:10.1002/jemt.20592]

The reservosome lumen is the internal volume of a T. cruzi reservosome and is bounded by the reservosome membrane.

Subject	Predicate	Object	Evidence
reservosome lumen	is part of	reservosome	`GO:0106124` GO:0106124 is the reservosome lumen cellular-component term. `GO:0106123` GO:0106123 identifies the containing reservosome organelle.
reservosome membrane	bounds	reservosome lumen	`GO:0106124` GO:0106124 defines the reservosome lumen as the volume enclosed by reservosome membranes. `GO:0106126` GO:0106126 identifies the lipid bilayer surrounding a reservosome.

INTERPRETATION (RESOLVED): Represent the reservosome matrix as a separate internal substructure rather than duplicating its membranes, vesicles, or lipid inclusions as direct lumen components. GO:0106124 denotes the volume enclosed by reservosome membranes, whereas GO:0106125 denotes the internal reservosome matrix composed of planar membranes, vesicles, and lipid inclusions.

GO:0106124 Gene Ontology cellular-component term for the reservosome lumen, defined as the volume enclosed by the membranes of a reservosome.
GO:0110165 Gene Ontology cellular-component parent term for cellular anatomical structures.
GO:0106123 Gene Ontology cellular-component term for the containing reservosome organelle.
GO:0106126 Gene Ontology cellular-component term for the lipid-bilayer reservosome membrane that bounds the lumen.
GO:0106125 Gene Ontology cellular-component term for the distinct reservosome matrix inside the reservosome.
PMID:18452191 PubMed record for the Sant'Anna et al. 2008 reservosome ultrastructure study.
DOI:10.1002/jemt.20592 Sant'Anna et al. 2008, New insights into the morphology of Trypanosoma cruzi reservosome, Microscopy Research and Technique.
DOI:10.1017/S0031182004005797 Figueiredo et al. 2004, Reservosome: an endocytic compartment in epimastigote forms of the protozoan Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae), Parasitology.
DOI:10.1002/pmic.200800730 Sant'Anna et al. 2009, Subcellular proteomics of Trypanosoma cruzi reservosomes, Proteomics.

2026-10-03T00:14:47Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-10-03T00:15:39Z codex · EXPANDED_RECORD — Added GO parthood and parentage, Trypanosoma cruzi epimastigote scope, GO/DOI/PMID evidence, a nonmechanistic reservosome-lumen topology graph, and a resolved boundary interpretation that leaves reservosome-matrix constituents on the matrix record.
2026-10-03T00:29:25Z codex · ADDRESS_PR_REVIEW — Resolved #1957 by narrowing the reservosome lumen canonical example to T. cruzi ultrastructure evidence and removing hydrolase and cargo claims from the single-citation example.