trans-Golgi network membrane

GO:0032588 · Membrane organelle · Membrane · Proposed

The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network. [GO:0032588]

Synonyms: trans Golgi network membrane

Part of: trans-Golgi network (GO:0005802)

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
trans-Golgi network membrane lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Lipid-bilayer constituent of the trans-Golgi network membrane. `GO:0032588` GO:0032588 defines the trans-Golgi network membrane as the lipid bilayer around compartments that make up the trans-Golgi network.

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Holthuis et al. characterized Tlg1p and Tlg2p as Saccharomyces syntaxins in the TGN/endosomal system. [DOI:10.1093/emboj/17.1.113]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which Ent3p and Ent5p adaptor functions in protein trafficking between the trans-Golgi network and endosomes were dissected. [DOI:10.1091/MBC.E06-11-1000]

The trans-Golgi network membrane bounds TGN compartments that participate in yeast traffic between late Golgi and endosomal compartments.

Subject	Predicate	Object	Evidence
trans-Golgi network membrane	bounds	trans-Golgi network	`GO:0032588` GO:0032588 defines the membrane surrounding trans-Golgi network compartments.
trans-Golgi network membrane	supports	TGN/endosomal protein sorting	`DOI:10.1093/emboj/17.1.113` Holthuis et al. 1998 characterized the yeast TGN/endosomal system through the syntaxins Tlg1p and Tlg2p. `DOI:10.1091/MBC.E06-11-1000` Copic et al. 2007 studied Ent3p/Ent5p roles in trafficking proteins between the yeast TGN and endosomes.
TGN/endosomal protein sorting	connects	endosome	`DOI:10.1091/MBC.E06-11-1000` Copic et al. 2007 framed Ent3p/Ent5p-dependent cargo sorting as protein trafficking between the trans-Golgi network and endosomes in yeast.

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the lipid constituent of the trans-Golgi network membrane. The record is exactly grounded to GO:0032588, but the TGN membrane lipid-bilayer constituent is intentionally left as reviewed-label-only until an exact source-neutral lipid or membrane-constituent CURIE is curated.
INTERPRETATION (RESOLVED): Keep Tlg SNAREs and Ent adaptor proteins out of the trans-Golgi network membrane structural-component list until exact source-neutral families are curated and a constituent-versus-trafficking-machinery boundary is reviewed. Holthuis et al. 1998 and Copic et al. 2007 support TGN/endosomal membrane traffic through Tlg1p, Tlg2p, Ent3p and Ent5p, but this initial membrane record does not treat those trafficking factors as lipid-bilayer constituents of the TGN membrane itself.

GO:0032588 Gene Ontology cellular-component term for trans-Golgi network membrane.
GO:0000139 Gene Ontology cellular-component parent term for Golgi membrane.
GO:0005802 Gene Ontology cellular-component term for trans-Golgi network.
GO:0005794 Gene Ontology cellular-component term for Golgi apparatus.
GO:0005768 Gene Ontology cellular-component term for endosome.
DOI:10.1093/emboj/17.1.113 Holthuis et al. 1998, 'Two syntaxin homologues in the TGN/endosomal system of yeast', EMBO Journal.
DOI:10.1091/MBC.E06-11-1000 Copic et al. 2007, 'Ent3p and Ent5p exhibit cargo-specific functions in trafficking proteins between the trans-Golgi network and the endosomes in yeast', Molecular Biology of the Cell.

2026-09-14T04:54:23Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-14T04:54:53Z codex · EXPANDED_RECORD — Added Golgi-membrane parentage, trans-Golgi-network parthood, a reviewed-label-only TGN membrane lipid bilayer component, Saccharomyces scope, GO/DOI evidence, a nonmechanistic TGN membrane traffic graph, and lipid-grounding plus trafficking-factor boundary discussions.