clathrin coat of coated pit

GO:0030132 · Other · Multiprotein complex · Proposed

The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex. [GO:0030132]

Part of: clathrin-coated pit (GO:0005905)

Has part: AP-2 adaptor complex (GO:0030122)

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
clathrin triskelion scaffold	Protein complex	part of	Reviewed label only (reviewed name; no accession asserted)			UNKNOWN	Polymerized clathrin triskelions that build the lattice of the coated-pit clathrin coat. `GO:0030132` GO:0030132 defines the clathrin coat of a coated pit as comprising clathrin and AP-2. `GO:0030118` GO:0030118 defines clathrin coats as polymerized clathrin triskelions linked to membranes by adaptor complexes.
AP-2 adaptor complex	Protein complex	part of	`GO:0030122`			UNKNOWN	Endocytic AP-type adaptor complex that links clathrin to coated-pit membranes and cargo receptors. `GO:0030132` GO:0030132 states that the clathrin coat of a coated pit comprises clathrin and the AP-2 adaptor complex. `GO:0030122` GO:0030122 has a part-of relationship to the clathrin coat of a coated pit. `DOI:10.1016/S0092-8674(02)00735-3` Collins, McCoy, Kent, Evans and Owen 2002 determined the molecular architecture of the endocytic AP-2 complex. `DOI:10.1016/j.cell.2010.05.006` Jackson et al. 2010 analyzed AP-2 membrane recruitment and cargo binding by the AP-2 clathrin adaptor complex.

clathrin-dependent endocytosis GO:0072583 — The clathrin coat of coated pits participates in clathrin-dependent endocytosis by forming the AP-2/clathrin coat on endocytic coated pits.
- GO:0072583 GO:0072583 describes endocytosis through clathrin-coated pits that form clathrin-coated endocytic vesicles.
- GO:0030132 GO:0030132 identifies the clathrin/AP-2 coat on coated pits.

The clathrin coat of a coated pit is an AP-2-containing clathrin coat on a clathrin-coated pit and participates in clathrin-dependent endocytosis.

Subject	Predicate	Object	Evidence
clathrin triskelion scaffold	polymerizes into	clathrin coat of coated pit	`GO:0030118` GO:0030118 defines clathrin coats as polymerized clathrin triskelions. `GO:0030132` GO:0030132 identifies the coated-pit-specific clathrin coat.
AP-2 adaptor complex	is part of	clathrin coat of coated pit	`GO:0030122` GO:0030122 is directly part of GO:0030132. `DOI:10.1016/S0092-8674(02)00735-3` Collins, McCoy, Kent, Evans and Owen 2002 determined the endocytic AP-2 core architecture.
clathrin coat of coated pit	is part of	clathrin-coated pit	`GO:0005905` GO:0005905 identifies GO:0030132 as a part of the clathrin-coated pit.
clathrin coat of coated pit	participates in	clathrin-dependent endocytosis	`GO:0072583` GO:0072583 describes endocytosis through clathrin-coated pits that form clathrin-coated endocytic vesicles.

INTERPRETATION (RESOLVED): Keep the clathrin coat of coated pit distinct from the clathrin coat of an endocytic vesicle. GO:0030132 is the AP-2-containing clathrin coat on a clathrin-coated pit, whereas GO:0030128 is the clathrin coat of an endocytic vesicle. This record therefore places GO:0030132 under the broader clathrin coat and models GO:0005905 clathrin-coated pit as the containing structure rather than treating the coated-pit and endocytic-vesicle coats as interchangeable.
CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the clathrin triskelion scaffold. The coated-pit coat has an exact GO identifier and AP-2 is modeled as an exact GO subcomplex, but the clathrin triskelion is currently represented at the source-neutral label level until an exact Complex Portal or GO grounding is curated.

GO:0030132 Gene Ontology cellular-component term for the clathrin coat of a coated pit.
GO:0030118 Gene Ontology cellular-component parent term for clathrin coats.
GO:0005905 Gene Ontology cellular-component term for the clathrin-coated pit that carries GO:0030132 as a part.
GO:0030122 Gene Ontology cellular-component term for the AP-2 adaptor complex part of GO:0030132.
GO:0072583 Gene Ontology biological-process term for clathrin-dependent endocytosis.
DOI:10.1016/S0092-8674(02)00735-3 Collins, McCoy, Kent, Evans and Owen 2002, Molecular Architecture and Functional Model of the Endocytic AP2 Complex, Cell.
DOI:10.1016/j.cell.2010.05.006 Jackson et al. 2010, A Large-Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the AP2 Clathrin Adaptor Complex, Cell.

2026-09-16T15:07:00Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-16T15:08:28Z codex · EXPANDED_RECORD — Added clathrin-coat parentage, clathrin-coated-pit parthood, AP-2 has-part topology, reviewed-label-only clathrin triskelion and GO-grounded AP-2 components, GO/DOI evidence, a nonmechanistic coated-pit topology graph, and boundary and grounding discussions.
2026-09-16T15:16:37Z codex · ADDRESSED_PR_REVIEW — Resolved PR #1104 review issue #1105 by changing the coated-pit function description so the structure forms the AP-2/clathrin coat rather than organizing another AP-2/clathrin coat.
2026-09-20T21:55:39Z codex · ADDRESSED_REVIEW — Retyped the AP-2 adaptor complex graph node as STRUCTURE.