Ctf18 RFC-like complex
A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p. [GO:0031390]
Synonyms: Ctf18-RFC; Ctf18-RLC; RFC (Ctf18)
Components
| Component | Type | Part of / acts on | Grounding | Genes | Stoichiometry | Essential | Role |
|---|---|---|---|---|---|---|---|
| Ctf18 subunit | Protein | part of | Reviewed label only (reviewed name; no accession asserted) | CTF18 | UNKNOWN | Named Saccharomyces cerevisiae constituent of the heptameric Ctf18 RFC-like complex.
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| Rfc2 subunit | Protein | part of | Reviewed label only (reviewed name; no accession asserted) | RFC2 | UNKNOWN | Named Saccharomyces cerevisiae constituent of the heptameric Ctf18 RFC-like complex.
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| Rfc3 subunit | Protein | part of | Reviewed label only (reviewed name; no accession asserted) | RFC3 | UNKNOWN | Named Saccharomyces cerevisiae constituent of the heptameric Ctf18 RFC-like complex.
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| Rfc4 subunit | Protein | part of | Reviewed label only (reviewed name; no accession asserted) | RFC4 | UNKNOWN | Named Saccharomyces cerevisiae constituent of the heptameric Ctf18 RFC-like complex.
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| Rfc5 subunit | Protein | part of | Reviewed label only (reviewed name; no accession asserted) | RFC5 | UNKNOWN | Named Saccharomyces cerevisiae constituent of the heptameric Ctf18 RFC-like complex.
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| Dcc1 subunit | Protein | part of | Reviewed label only (reviewed name; no accession asserted) | DCC1 | UNKNOWN | Named Saccharomyces cerevisiae constituent of the heptameric Ctf18 RFC-like complex.
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| Ctf8 subunit | Protein | part of | Reviewed label only (reviewed name; no accession asserted) | CTF8 | UNKNOWN | Named Saccharomyces cerevisiae constituent of the heptameric Ctf18 RFC-like complex.
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Taxonomic distribution
NCBITaxon:4932Saccharomyces cerevisiae — COMMON: Budding yeast has a heptameric Ctf18 RFC-like complex containing Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p and Ctf8p. [GO:0031390]
Canonical examples
NCBITaxon:4932Saccharomyces cerevisiae — Reference budding-yeast system named in the GO:0031390 definition as containing Ctf18p, the four small RFC subunits, Dcc1p and Ctf8p. [GO:0031390]
Functions
- DNA clamp loader activity
GO:0003689— The Ctf18 RFC-like complex loads the PCNA sliding clamp onto DNA.GO:0031390GO:0031390 defines the Ctf18 RFC-like complex as loading PCNA onto DNA.GO:0003689GO:0003689 is the Gene Ontology molecular-function term for DNA clamp loader activity.
- sister chromatid cohesion
GO:0007062— The Ctf18 RFC-like complex supports cohesion of replicated chromosomes.GO:0031390GO:0031390 defines the Ctf18 RFC-like complex as playing a vital role in chromosome cohesion.GO:0007062GO:0007062 is the Gene Ontology biological-process term for sister chromatid cohesion.
Mechanism graphs
Ctf18-RFC loads PCNA and supports cohesion (FUNCTION)
Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p and Ctf8p form the Saccharomyces cerevisiae Ctf18 RFC-like complex that loads PCNA onto DNA and supports chromosome cohesion.
| Subject | Predicate | Object | Evidence |
|---|---|---|---|
| Ctf18 subunit | contributes to | Ctf18 RFC-like complex |
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| Rfc2 subunit | contributes to | Ctf18 RFC-like complex |
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| Rfc3 subunit | contributes to | Ctf18 RFC-like complex |
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| Rfc4 subunit | contributes to | Ctf18 RFC-like complex |
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| Rfc5 subunit | contributes to | Ctf18 RFC-like complex |
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| Dcc1 subunit | contributes to | Ctf18 RFC-like complex |
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| Ctf8 subunit | contributes to | Ctf18 RFC-like complex |
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| Ctf18 RFC-like complex | supports | DNA clamp loader activity |
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| Ctf18 RFC-like complex | supports | sister chromatid cohesion |
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Discussions
- CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the Ctf18, Rfc2, Rfc3, Rfc4, Rfc5, Dcc1 and Ctf8 constituents of the Ctf18 RFC-like complex. GO:0031390 exactly identifies the Ctf18 RFC-like complex and names the budding-yeast Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p and Ctf8p constituents, but exact source-neutral InterPro, Pfam, NCBIfam or UniProtKB family CURIEs for these subunit classes were not curated in this pass.
Evidence
GO:0031390Gene Ontology cellular-component term for the Ctf18 RFC-like complex.GO:0140513Gene Ontology cellular-component parent term for nuclear protein-containing complexes.GO:0003689Gene Ontology molecular-function term for DNA clamp loader activity.GO:0007062Gene Ontology biological-process term for sister chromatid cohesion.PMID:14614842PubMed identifier for Kim and MacNeill 2003, the Current Biology review listed as the GO:0031390 definition source.DOI:10.1016/j.cub.2003.10.048DOI for Kim and MacNeill 2003, verified through PubMed as the GO:0031390 definition-source review.
Curation history
2026-09-27T13:54:48Zcodex · CREATED_RECORD — Scaffolded by scripts/new_record.py2026-09-27T13:55:39Zcodex · EXPANDED_RECORD — Added GO Ctf18-RFC synonymy, nuclear protein-containing-complex parentage, seven reviewed-label-only budding-yeast constituent rows, Saccharomyces cerevisiae scope, clamp-loader and sister-chromatid-cohesion function evidence, GO/PubMed/DOI evidence, a nonmechanistic function graph, and a Ctf18-RFC subunit-grounding TODO.