Cvt complex

GO:0034270 · Other · Multiprotein complex · Proposed

A protein complex that is involved in the Cvt pathway. In budding yeast, the Cvt complex consists of multimers of preApe1p. [GO:0034270]

Synonyms: cytoplasm to vacuole targeting complex; cytoplasm-to-vacuole targeting complex

Part of: GO:0005737 — cytoplasm (no local record)

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
precursor aminopeptidase I	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	APE1		ESSENTIAL	Budding-yeast proApe1 cargo constituent that multimerizes to form the Cvt complex recognized for selective vacuolar delivery. `GO:0034270` GO:0034270 defines the budding-yeast Cvt complex as a preApe1p-containing protein complex. `DOI:10.1016/s1097-2765(01)00263-5` Scott et al. 2001 identified Cvt19/Atg19 as a receptor that links precursor aminopeptidase I cargo to Cvt-pathway delivery. `DOI:10.1074/jbc.M404399200` Shintani and Klionsky 2004 analyzed Ape1 cargo as a determinant of Cvt vesicle formation.

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast assembles preApe1p-containing Cvt complexes for selective cytoplasm-to-vacuole targeting. [DOI:10.1016/s1097-2765(01)00263-5]

NCBITaxon:4932 Saccharomyces cerevisiae — Model yeast used to define receptor-mediated delivery of precursor aminopeptidase I cargo through the Cvt pathway. [DOI:10.1016/s1097-2765(01)00263-5]

Precursor aminopeptidase I multimerizes into the Cvt complex, which is then selectively enclosed by Cvt vesicles before vacuolar delivery.

Subject	Predicate	Object	Evidence
precursor aminopeptidase I	is part of	Cvt complex	`GO:0034270` GO:0034270 defines the Cvt complex as a preApe1p-containing protein complex.
Cvt complex	is enclosed by	Cvt vesicle	`GO:0032258` GO:0032258 defines Cvt-pathway delivery as formation of a Cvt complex and expansion of a membrane around it.
Cvt vesicle	supports	cytoplasm to vacuole targeting by the Cvt pathway	`GO:0033107` GO:0033107 defines Cvt vesicles by their involvement in the Cvt pathway.

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the Cvt precursor-aminopeptidase-I cargo constituent. This first Cvt complex record represents the GO-defined budding-yeast proApe1 cargo constituent, while leaving exact InterPro or Pfam grounding unset until the aminopeptidase family boundary has been reviewed.
CURATION_TODO (RESOLVED): Do not model Atg19 or Atg11 as constituent Cvt complex components. Atg19/Cvt19 recognizes precursor aminopeptidase I cargo and Atg11 moves the resulting Cvt complex to the phagophore assembly site, but the GO:0034270 record boundary is the preApe1p-containing Cvt cargo complex rather than those pathway adaptors.

GO:0034270 Gene Ontology cellular-component term for the Cvt complex.
GO:0032991 Gene Ontology cellular-component parent term for protein-containing complexes.
GO:0005737 — cytoplasm Gene Ontology cellular-component term for the cytoplasm.
GO:0032258 Gene Ontology biological-process term for cytoplasm to vacuole targeting by the Cvt pathway.
GO:0033107 Gene Ontology cellular-component term for the Cvt vesicle that sequesters the Cvt complex.
DOI:10.1016/s1097-2765(01)00263-5 Scott et al. 2001, Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway, Molecular Cell.
DOI:10.1074/jbc.M404399200 Shintani and Klionsky 2004, Cargo proteins facilitate the formation of transport vesicles in the cytoplasm to vacuole targeting pathway, Journal of Biological Chemistry.

2026-09-30T06:38:16Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-30T06:40:23Z codex · EXPANDED_RECORD — Added Cvt-complex synonymy, protein-complex parentage, cytoplasm parthood, a reviewed-label-only precursor aminopeptidase I constituent, Saccharomyces cerevisiae scope, a Cvt-pathway function, GO/DOI evidence, a nonmechanistic Cvt cargo-delivery graph, and grounding and Atg receptor/scaffold boundary discussions.
2026-09-30T07:06:22Z codex · ADDRESS_REVIEW — Resolved #1813 by removing the passive Cvt-pathway function row while retaining GO:0032258 as evidence for Cvt-complex enclosure in the cargo-delivery graph.