Elg1 RFC-like complex
A pentameric replication factor C-like complex that unloads the proliferating cell nuclear antigen DNA clamp from chromatin and supports telomere length regulation and genome stability in Saccharomyces. [GO:0031391]
Synonyms: Elg1-RFC; Elg1-RLC; RFC (Elg1)
Components
| Component | Type | Part of / acts on | Grounding | Genes | Stoichiometry | Essential | Role |
|---|---|---|---|---|---|---|---|
| Elg1 subunit | Protein | part of | Reviewed label only (reviewed name; no accession asserted) | ELG1 | UNKNOWN | Named Saccharomyces constituent of the pentameric Elg1 RFC-like complex.
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| Rfc2 subunit | Protein | part of | Reviewed label only (reviewed name; no accession asserted) | RFC2 | UNKNOWN | Named Saccharomyces constituent of the pentameric Elg1 RFC-like complex.
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| Rfc3 subunit | Protein | part of | Reviewed label only (reviewed name; no accession asserted) | RFC3 | UNKNOWN | Named Saccharomyces constituent of the pentameric Elg1 RFC-like complex.
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| Rfc4 subunit | Protein | part of | Reviewed label only (reviewed name; no accession asserted) | RFC4 | UNKNOWN | Named Saccharomyces constituent of the pentameric Elg1 RFC-like complex.
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| Rfc5 subunit | Protein | part of | Reviewed label only (reviewed name; no accession asserted) | RFC5 | UNKNOWN | Named Saccharomyces constituent of the pentameric Elg1 RFC-like complex.
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Taxonomic distribution
NCBITaxon:4932Saccharomyces cerevisiae — COMMON: Budding yeast has an Elg1 RFC-like complex containing Elg1p, Rfc2p, Rfc3p, Rfc4p and Rfc5p. [GO:0031391]
Canonical examples
NCBITaxon:4932Saccharomyces cerevisiae — Reference budding-yeast system named in the GO:0031391 definition as containing Elg1p and the four small RFC subunits. [GO:0031391]
Functions
- DNA clamp unloader activity
GO:0061860— The Elg1 RFC-like complex unloads the PCNA DNA clamp from chromatin.GO:0031391GO:0031391 defines the Elg1 RFC-like complex as unloading PCNA from chromatin.GO:0061860GO:0061860 is the Gene Ontology molecular-function term for DNA clamp unloader activity.
Mechanism graphs
Elg1-RFC unloads PCNA (FUNCTION)
Elg1p, Rfc2p, Rfc3p, Rfc4p and Rfc5p form the Saccharomyces Elg1 RFC-like complex that unloads the PCNA DNA clamp from chromatin.
| Subject | Predicate | Object | Evidence |
|---|---|---|---|
| Elg1 subunit | contributes to | Elg1 RFC-like complex |
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| Rfc2 subunit | contributes to | Elg1 RFC-like complex |
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| Rfc3 subunit | contributes to | Elg1 RFC-like complex |
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| Rfc4 subunit | contributes to | Elg1 RFC-like complex |
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| Rfc5 subunit | contributes to | Elg1 RFC-like complex |
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| Elg1 RFC-like complex | supports | DNA clamp unloader activity |
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Discussions
- CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the Elg1, Rfc2, Rfc3, Rfc4 and Rfc5 constituents of the Elg1 RFC-like complex. GO:0031391 exactly identifies the Elg1 RFC-like complex and names the Saccharomyces Elg1p, Rfc2p, Rfc3p, Rfc4p and Rfc5p constituents, but exact source-neutral InterPro, Pfam, NCBIfam or UniProtKB family CURIEs for these subunit classes were not curated in this pass.
Evidence
GO:0031391Gene Ontology cellular-component term for the Elg1 RFC-like complex.GO:0032991Gene Ontology cellular-component parent term for protein-containing complexes.GO:0061860Gene Ontology molecular-function term for DNA clamp unloader activity.PMID:14614842PubMed identifier listed by GO:0031391 as a definition cross-reference.PMID:23499004PubMed identifier listed by GO:0031391 and GO:0061860 as a definition cross-reference.PMID:27664980PubMed identifier listed by GO:0031391 as a definition cross-reference.
Curation history
2026-09-27T15:44:52Zcodex · CREATED_RECORD — Scaffolded by scripts/new_record.py2026-09-27T15:46:11Zcodex · EXPANDED_RECORD — Added GO Elg1-RFC synonymy, protein-containing-complex parentage, five reviewed-label-only Saccharomyces constituent rows, Saccharomyces cerevisiae scope, DNA clamp unloader function evidence, GO/PubMed evidence, a nonmechanistic function graph, and an Elg1-RFC subunit-grounding TODO.