FMN reductase complex

GO:1990202 · Other · Multiprotein complex · Proposed

A protein complex capable of FMN reductase activity. Reduces FMN to FMNH2 in a NAD(P)H-dependent manner. In E.coli, consists of a SsuE dimer. [GO:1990202]

Synonyms: FMN reductase complex, NAD(P)H-dependent; SsuE complex

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
NADPH-dependent FMN reductase, SsuE	Protein	part of	`InterPro:IPR020048`	ssuE	2 copies per E. coli SsuE dimer described by GO:1990202	UNKNOWN	FMN reductase subunit that homodimerizes to reduce FMN to FMNH2 in the E. coli alkanesulfonate monooxygenase system. `GO:1990202` GO:1990202 defines the E. coli FMN reductase complex as a SsuE dimer. `InterPro:IPR020048` InterPro IPR020048 is the NADPH-dependent FMN reductase, SsuE family entry. `PMID:10480865` Eichhorn et al. 1999 characterized SsuE as the E. coli FMN reductase that provides FMNH2 to SsuD.

Organism-specific protein examples

Named proteins in which each component's role was established, with the organism the evidence comes from. The component above is the taxon-agnostic family; these are the specific entries behind it.

NADPH-dependent FMN reductase, SsuE

Accession	Protein	Gene	Organism	Entry
`UniProtKB:P80644`	FMN reductase (NADPH)	ssuE	Escherichia coli K-12 (`NCBITaxon:83333`)	REVIEWED
Role and evidence (2 references) Reviewed E. coli K-12 SsuE accession for the FMN-reducing homodimer represented by GO:1990202. `UniProtKB:P80644` UniProtKB P80644 is the reviewed E. coli K-12 entry for SsuE FMN reductase. `PMID:10480865` Eichhorn et al. 1999 characterized E. coli SsuE as the FMN-reducing enzyme in the alkanesulfonate monooxygenase system.

Canonical examples

NCBITaxon:562 Escherichia coli — E. coli source of the NADPH-dependent SsuE FMN reductase characterized in the alkanesulfonate monooxygenase system. [PMID:10480865]

Functions

FMN reductase (NADPH) activity GO:0052873 — The E. coli SsuE FMN reductase complex reduces FMN with NADPH.
- GO:1990202 GO:1990202 defines the complex by NAD(P)H-dependent FMN reduction.
- GO:0052873 GO:0052873 is the molecular-function term for NADPH-dependent FMN reductase activity.

Physical properties

SUBUNIT_COUNT: 2 (E. coli SsuE dimer described by GO:1990202) [GO:1990202]

Evidence

GO:1990202 Gene Ontology cellular-component term for the FMN reductase complex.
GO:1990204 QuickGO reports GO:1990202 as an is-a descendant of GO:1990204 oxidoreductase complex.
GO:0052873 Gene Ontology molecular-function term for FMN reductase (NADPH) activity.
InterPro:IPR020048 InterPro family entry for NADPH-dependent FMN reductase, SsuE.
UniProtKB:P80644 UniProtKB reviewed E. coli K-12 SsuE entry.
PMID:10480865 PubMed identifier for Eichhorn, van der Ploeg and Leisinger 1999, the Journal of Biological Chemistry SsuD/SsuE characterization paper cited by GO:1990202.
DOI:10.1074/jbc.274.38.26639 DOI for the GO:1990202-cited SsuD/SsuE characterization paper.

Curation history

2026-10-01T21:33:06Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-10-01T21:33:48Z codex · EXPANDED_RECORD — Added GO exact and narrow synonymy, GO:1990204 oxidoreductase-complex parentage, an InterPro-grounded SsuE component with a reviewed E. coli K-12 UniProt example, an E. coli canonical example, NADPH-dependent FMN reductase activity, dimer subunit count, and PMID/DOI evidence.

Source: data/structures/other/fmn_reductase_complex.yaml