GET complex

GO:0043529 · Other · Multiprotein complex · Proposed

An endoplasmic reticulum protein-containing complex that is conserved in eukaryotes and mediates the insertion of tail-anchored proteins into the ER membrane. [GO:0043529]

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast contains the GET complex, with Get3 coupling tail-anchored substrates to the Get1/Get2 ER receptor during ER-membrane insertion. [DOI:10.1016/j.cell.2008.06.025]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which Get3 recognition of secretory-pathway tail anchors, Get1/Get2 receptor recruitment to the ER, and direct Get-mediated insertion were connected experimentally. [DOI:10.1016/j.cell.2008.06.025]

Functions

tail-anchored membrane protein insertion into ER membrane GO:0071816 — GET mediates post-translational delivery and insertion of newly synthesized tail-anchored proteins into the endoplasmic-reticulum membrane.
- GO:0071816 GO:0071816 denotes tail-anchored membrane protein insertion into the endoplasmic-reticulum membrane.
- DOI:10.1016/j.cell.2008.06.025 Schuldiner et al. 2008 showed in budding yeast that Get3 recognizes secretory-pathway tail-anchored protein transmembrane domains, that Get1/Get2 recruits Get3-TA complexes to the ER, and that purified Get proteins directly mediate insertion in vitro.

Mechanism graphs

GET mediates tail-anchored ER insertion (FUNCTION)

The GET complex is an endoplasmic-reticulum protein complex that recognizes tail-anchored substrates and mediates their insertion into the ER membrane.

Subject	Predicate	Object	Evidence
GET complex	supports	tail-anchored membrane protein insertion into ER membrane	`GO:0043529` GO:0043529 defines GET by its mediation of tail-anchored protein insertion into the ER membrane. `DOI:10.1016/j.cell.2008.06.025` Schuldiner et al. 2008 reconstituted Get-dependent insertion of newly synthesized tail-anchored proteins into ER membranes.
GET complex	inserts substrates into	endoplasmic reticulum membrane	`GO:0071816` GO:0071816 denotes tail-anchored membrane protein insertion specifically into the ER membrane. `DOI:10.1016/j.cell.2008.06.025` Schuldiner et al. 2008 linked Get1/Get2 receptor recruitment to in vitro insertion of tail-anchored proteins into ER membranes.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral GET subunit groundings and the boundary between the Get1/Get2 receptor, the Get3 targeting factor, and upstream pretargeting factors before adding component rows. GO exactly grounds the GET complex and names yeast Get1p, Get2p and Get3p in its definition, but exact source-neutral families and the membership boundary for cytosolic pretargeting factors were not curated in this pass.

Evidence

GO:0043529 Gene Ontology cellular-component term for the GET complex.
GO:0140534 Gene Ontology parent term for endoplasmic reticulum protein-containing complexes.
GO:0071816 Gene Ontology biological-process term for tail-anchored membrane protein insertion into the ER membrane.
GO:0005789 Gene Ontology cellular-component term for the endoplasmic reticulum membrane, the target membrane in GO:0071816.
DOI:10.1016/j.cell.2008.06.025 Schuldiner et al. 2008, The GET complex mediates insertion of tail-anchored proteins into the ER membrane, Cell.

Curation history

2026-09-18T21:14:47Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-18T21:15:26Z codex · EXPANDED_RECORD — Added ER-protein-complex parentage, Saccharomyces scope, a GET-dependent tail-anchored insertion function, GO/DOI evidence, a nonmechanistic insertion graph, and a GET subunit-boundary TODO.
2026-09-18T21:26:05Z codex · ADDRESS_REVIEW — Resolved #1193 by clarifying Get3 versus Get1/Get2 receptor wording and resolved #1194 by adding ER membrane grounding and a function-graph ER membrane target node.

Source: data/structures/other/get_complex.yaml