MCM complex

GO:0042555 · Other · Multiprotein complex · Proposed

A hexameric protein complex required for the initiation and regulation of DNA replication. [GO:0042555]

Synonyms: mini-chromosome maintenance complex

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
MCM subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)		6	UNKNOWN	Protein constituent class that forms the hexameric MCM complex. `GO:0042555` GO:0042555 defines MCM as a hexameric protein complex required for the initiation and regulation of DNA replication. `PMID:11282021` The PubMed abstract for Lei and Tye 2001 identifies the eukaryotic MCM complex as a hexameric pre-replication-complex component.

NCBITaxon:2759 Eukaryota — COMMON: The Lei and Tye review describes the hexameric MCM complex as a key eukaryotic pre-replication-complex component. [PMID:11282021]

DNA replication GO:0006260 — The MCM complex supports the initiation and regulation of DNA replication.
- GO:0042555 GO:0042555 defines the MCM complex as required for the initiation and regulation of DNA replication.
- GO:0006260 GO:0006260 is the Gene Ontology biological-process term for DNA replication.
- PMID:11282021 The PubMed abstract for Lei and Tye 2001 reviews MCM recruitment to replication origins and activation of DNA synthesis.

MCM subunits form the hexameric MCM complex required for the initiation and regulation of DNA replication.

Subject	Predicate	Object	Evidence
MCM subunit	contributes to	MCM complex	`GO:0042555` GO:0042555 defines MCM as a hexameric protein complex. `PMID:11282021` The PubMed abstract for Lei and Tye 2001 identifies the eukaryotic MCM complex as hexameric.
MCM complex	supports	DNA replication	`GO:0042555` GO:0042555 defines the MCM complex as required for the initiation and regulation of DNA replication. `GO:0006260` GO:0006260 is the GO biological-process term for DNA replication.

CURATION_TODO (OPEN): Resolve exact source-neutral groundings and subtype boundaries for archaeal MCM, eukaryotic MCM2-7 and MCM8-MCM9 complex constituents. GO:0042555 exactly identifies the parent MCM complex and defines it as hexameric, while GO:0097362 identifies MCM8-MCM9 as a child of MCM. This record therefore models one generic hexamer-forming MCM subunit class instead of overclaiming six universal named subunits or collapsing MCM8-MCM9 into the parent complex.

GO:0042555 Gene Ontology cellular-component term for the MCM complex.
GO:0032991 Gene Ontology cellular-component parent term for protein-containing complexes.
GO:0006260 Gene Ontology biological-process term for DNA replication.
PMID:11282021 PubMed identifier listed by GO:0042555 as its definition cross-reference.
GO:0097362 Gene Ontology child cellular-component term for the MCM8-MCM9 complex.

2026-09-27T16:35:46Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-27T16:37:45Z codex · EXPANDED_RECORD — Added GO MCM synonymy, protein-containing-complex parentage, one generic reviewed-label-only hexameric constituent class, Eukaryota scope, DNA-replication function evidence, GO/PubMed evidence, a nonmechanistic function graph, and an MCM subtype/subunit-grounding TODO.