mitochondrial prohibitin complex

GO:0035632 · Other · Multiprotein complex · Proposed

Inner-mitochondrial-membrane macromolecular complex composed of repeating prohibitin 1 and prohibitin 2 heterodimeric subunits. [GO:0035632]

Synonyms: mitochondrial inner membrane prohibitin complex

Part of: mitochondrial inner membrane (GO:0005743)

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding-yeast mitochondria contain a membrane-associated prohibitin supercomplex built from PHB1 and PHB2 subunits. [DOI:10.1110/ps.0212602]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model used for chemical crosslinking and mass-spectrometry evidence that PHB1 and PHB2 form heterodimeric building blocks of the mitochondrial prohibitin supercomplex. [DOI:10.1110/ps.0212602]

mitochondrion organization GO:0007005 — The mitochondrial prohibitin complex contributes to mitochondrial biogenesis while associated with the mitochondrial inner membrane.
- GO:0035632 GO:0035632 defines the mitochondrial prohibitin complex as a PHB1/PHB2 inner-membrane supercomplex with a role in mitochondrial biogenesis.
- GO:0007005 GO:0007005 denotes mitochondrion organization and has mitochondrial biogenesis as an exact synonym.
- DOI:10.18632/aging.100246 Artal-Sanz and Tavernarakis 2010 reviewed the eukaryotic mitochondrial prohibitin complex as an inner-membrane macromolecular structure implicated in mitochondrial biogenesis among several cellular processes.

PHB1 and PHB2 build a mitochondrial inner-membrane prohibitin supercomplex implicated in mitochondrial biogenesis.

Subject	Predicate	Object	Evidence
mitochondrial prohibitin complex	is part of	mitochondrial inner membrane	`GO:0035632` GO:0035632 defines the complex as associated with the inner mitochondrial membrane.
mitochondrial prohibitin complex	supports	mitochondrion organization	`GO:0035632` GO:0035632 includes mitochondrial biogenesis among processes involving the PHB1/PHB2 prohibitin complex. `DOI:10.18632/aging.100246` Artal-Sanz and Tavernarakis 2010 reviewed the mitochondrial prohibitin complex as a eukaryotic inner-membrane macromolecular structure involved in mitochondrial biogenesis among several cellular processes.

CURATION_TODO (OPEN): Resolve exact source-neutral PHB1 and PHB2 family groundings before adding mitochondrial prohibitin component rows. GO exactly grounds the mitochondrial prohibitin complex and Back et al. identify PHB1 and PHB2 as budding-yeast subunits, but this first record leaves prohibitin 1 and prohibitin 2 rows unasserted until exact taxon-agnostic family identifiers are verified.

GO:0035632 Gene Ontology cellular-component term for the mitochondrial prohibitin complex.
GO:0098800 Gene Ontology cellular-component parent term for inner mitochondrial membrane protein complexes.
GO:0005743 Gene Ontology cellular-component term for the mitochondrial inner membrane with which the prohibitin complex is associated.
GO:0007005 Gene Ontology biological-process term for mitochondrion organization and biogenesis.
DOI:10.1110/ps.0212602 Back et al. 2002, 'A structure for the yeast prohibitin complex: Structure prediction and evidence from chemical crosslinking and mass spectrometry', Protein Science.
DOI:10.18632/aging.100246 Artal-Sanz and Tavernarakis 2010, 'Opposing function of mitochondrial prohibitin in aging', Aging.

2026-09-18T19:03:53Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-18T19:04:47Z codex · EXPANDED_RECORD — Added GO synonymy, inner-mitochondrial-membrane protein-complex parentage, mitochondrial-inner-membrane parthood, Saccharomyces scope, mitochondrion-organization function evidence, a nonmechanistic prohibitin function graph, and a prohibitin subunit-boundary TODO.
2026-09-18T19:15:29Z codex · ADDRESS_REVIEW — Resolved #1183 by narrowing the GO:0007005 function and graph prose from mitochondrial biogenesis and function to mitochondrial biogenesis.