Mpp10 complex

GO:0034457 · Other · Multiprotein complex · Proposed

A protein complex that forms a subcomplex of the 90S preribosome. In S. cerevisiae, it is composed of Mpp10p, Imp3p and Imp4p. [GO:0034457]

Part of: nucleolus (GO:0005730); 90S preribosome (GO:0030686)

Components

Component	Type	Part of / acts on	Grounding	Genes	Essential	Role
Mpp10 Mpp10-complex subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	MPP10	UNKNOWN	Protein constituent of the budding-yeast Mpp10 complex / 90S-preribosome subcomplex. `GO:0034457` GO:0034457 defines the Mpp10 complex as containing Mpp10p.
Imp3 Mpp10-complex subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	IMP3	UNKNOWN	Protein constituent of the budding-yeast Mpp10 complex / 90S-preribosome subcomplex. `GO:0034457` GO:0034457 defines the Mpp10 complex as containing Imp3p.
Imp4 Mpp10-complex subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	IMP4	UNKNOWN	Protein constituent of the budding-yeast Mpp10 complex / 90S-preribosome subcomplex. `GO:0034457` GO:0034457 defines the Mpp10 complex as containing Imp4p.

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast is the organism in which GO:0034457 defines the Mpp10 complex as a three-protein subcomplex of the 90S preribosome. [GO:0034457]

NCBITaxon:4932 Saccharomyces cerevisiae — Perez-Fernandez et al. 2007 placed the Mpp10 complex in the Pwp2p/UTP-B branch of stepwise 90S-preribosome assembly in budding yeast. [DOI:10.1128/MCB.00380-07]

90S preribosome assembly GO:0034463 — The Mpp10 complex forms a subcomplex of the 90S preribosome and participates in a stepwise assembly route for the yeast 90S preribosomal particle.
- GO:0034457 GO:0034457 defines the Mpp10 complex as a subcomplex of the 90S preribosome.
- GO:0034463 GO:0034463 is the Gene Ontology biological-process term for 90S preribosome assembly.
- DOI:10.1128/MCB.00380-07 Perez-Fernandez et al. 2007 placed the Mpp10p complex with the U3 snoRNP and Pwp2p/UTP-B subunit in one 90S-preribosome assembly intermediate.

In Saccharomyces cerevisiae, the three-protein Mpp10 complex forms a subcomplex of the 90S preribosome and joins the hierarchical assembly pathway.

Subject	Predicate	Object	Evidence
Mpp10 Mpp10-complex subunit	contributes to	Mpp10 complex	`GO:0034457` GO:0034457 defines Mpp10p as a component of the Mpp10 complex.
Imp3 Mpp10-complex subunit	contributes to	Mpp10 complex	`GO:0034457` GO:0034457 defines Imp3p as a component of the Mpp10 complex.
Imp4 Mpp10-complex subunit	contributes to	Mpp10 complex	`GO:0034457` GO:0034457 defines Imp4p as a component of the Mpp10 complex.
Mpp10 complex	part of	90S preribosome	`GO:0034457` GO:0034457 records Mpp10 as part of the 90S preribosome.
Mpp10 complex	supports	90S preribosome assembly	`GO:0034457` GO:0034457 defines Mpp10 as a subcomplex of the 90S preribosome. `GO:0034463` GO:0034463 is the process term for 90S preribosome assembly. `DOI:10.1128/MCB.00380-07` Perez-Fernandez et al. 2007 described the Mpp10p complex as a discrete assembly subunit that binds through the Pwp2p/UTP-B assembly route.

CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the Mpp10, Imp3 and Imp4 constituents of the Mpp10 complex. GO:0034457 uses Saccharomyces gene-product names while noting that analogous complexes in other eukaryotes can use the term. Exact cross-eukaryotic InterPro, Pfam, NCBIfam or UniProt family boundaries for the three Mpp10-complex proteins need narrower follow-up curation before these component labels can be grounded.

GO:0034457 Gene Ontology cellular-component term for the Mpp10 complex.
GO:0140513 Gene Ontology cellular-component parent term for nuclear protein-containing complexes.
GO:0005730 Gene Ontology cellular-component term for the nucleolus.
GO:0030686 Gene Ontology cellular-component term for the 90S preribosome.
GO:0034463 Gene Ontology biological-process term for 90S preribosome assembly.
PMID:17515605 PubMed identifier for Perez-Fernandez et al. 2007, the Molecular and Cellular Biology paper cited by GO:0034457.
DOI:10.1128/MCB.00380-07 DOI for Perez-Fernandez et al. 2007, 'The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism', verified through NCBI E-utilities.

2026-09-26T01:29:27Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-26T01:30:15Z codex · EXPANDED_RECORD — Added nuclear protein-containing complex parentage, nucleolar and 90S preribosome parthood, three reviewed-label-only Mpp10-complex constituent rows, budding-yeast scope, a 90S-preribosome-assembly function, GO/PubMed/DOI evidence, a nonmechanistic assembly graph, and an Mpp10-complex subunit-grounding TODO.