Mst2 histone acetyltransferase complex

GO:0036410 · Other · Multiprotein complex · Proposed

A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6. [GO:0036410]

Synonyms: Mst2 complex; Mst2 H3K14 acetyltransferase complex; Mst2 histone H3K14 acetyltransferase complex

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Essential	Role
Mst2 complex catalytic subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	mst2	UNKNOWN	MYST-family catalytic subunit of the fission-yeast Mst2 histone H3K14 acetyltransferase complex. `GO:0036410` GO:0036410 defines Mst2 as the Mst2-complex catalytic subunit. `DOI:10.1101/gad.1993611` Reddy et al. 2011 described Mst2 as the H3K14 acetyltransferase catalytic subunit.
Nto1 Mst2 complex subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	nto1	UNKNOWN	Protein constituent required for Mst2 histone H3K14 acetyltransferase activity in fission yeast. `GO:0036410` GO:0036410 defines Nto1 as a fission-yeast Mst2-complex constituent. `DOI:10.1101/gad.1993611` Reddy et al. 2011 identified Nto1 as an activity-essential Mst2-complex component.
Ptf2 Mst2 complex subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	ptf2	UNKNOWN	Protein constituent required for Mst2 histone H3K14 acetyltransferase activity in fission yeast. `GO:0036410` GO:0036410 defines Ptf2 as a fission-yeast Mst2-complex constituent. `DOI:10.1101/gad.1993611` Reddy et al. 2011 identified Ptf2 as an activity-essential Mst2-complex component.
Ptf1 Mst2 complex subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	ptf1	UNKNOWN	Protein constituent of the fission-yeast Mst2 complex that is not required for its acetyltransferase activity. `GO:0036410` GO:0036410 defines Ptf1 as a fission-yeast Mst2-complex constituent. `DOI:10.1101/gad.1993611` Reddy et al. 2011 identified Ptf1 as an Mst2-complex component.
Eaf6 Mst2 complex subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	eaf6	UNKNOWN	Protein constituent of the fission-yeast Mst2 complex that is not required for its acetyltransferase activity. `GO:0036410` GO:0036410 defines Eaf6 as a fission-yeast Mst2-complex constituent. `DOI:10.1101/gad.1993611` Reddy et al. 2011 identified Eaf6 as an Mst2-complex component.

Taxonomic distribution

NCBITaxon:4896 Schizosaccharomyces pombe — COMMON: Fission yeast is the organism in which GO:0036410 defines the Mst2 histone acetyltransferase complex as containing Mst2, Nto1, Ptf2, Ptf1 and Eaf6. [GO:0036410]

Canonical examples

NCBITaxon:4896 Schizosaccharomyces pombe — Reddy et al. 2011 studied the fission-yeast Mst2 complex in pericentric heterochromatin and distinguished Nto1/Ptf2 activity-essential subunits from Ptf1/Eaf6 subunits. [DOI:10.1101/gad.1993611]

Functions

histone H3K14 acetyltransferase activity GO:0036408 — The Mst2 complex catalyzes Mst2-dependent histone H3K14 acetylation in fission yeast.
- GO:0036410 GO:0036410 defines Mst2 as an H3K14 acetyltransferase complex.
- GO:0036408 GO:0036408 is the Gene Ontology molecular-function term for histone H3K14 acetyltransferase activity.
- DOI:10.1101/gad.1993611 Reddy et al. 2011 connected the Mst2 complex with fission-yeast H3K14 acetylation.

Mechanism graphs

Mst2 complex carries fission-yeast H3K14 acetyltransferase activity (FUNCTION)

In Schizosaccharomyces pombe, Mst2, Nto1, Ptf2, Ptf1 and Eaf6 form an Mst2 histone H3K14 acetyltransferase complex.

Subject	Predicate	Object	Evidence
Mst2 complex catalytic subunit	contributes to	Mst2 histone acetyltransferase complex	`GO:0036410` GO:0036410 defines Mst2 as the Mst2-complex catalytic subunit. `DOI:10.1101/gad.1993611` Reddy et al. 2011 described Mst2 as the H3K14 acetyltransferase catalytic subunit.
Nto1 Mst2 complex subunit	contributes to	Mst2 histone acetyltransferase complex	`GO:0036410` GO:0036410 defines Nto1 as a fission-yeast Mst2-complex constituent. `DOI:10.1101/gad.1993611` Reddy et al. 2011 identified Nto1 as an activity-essential Mst2-complex component.
Ptf2 Mst2 complex subunit	contributes to	Mst2 histone acetyltransferase complex	`GO:0036410` GO:0036410 defines Ptf2 as a fission-yeast Mst2-complex constituent. `DOI:10.1101/gad.1993611` Reddy et al. 2011 identified Ptf2 as an activity-essential Mst2-complex component.
Ptf1 Mst2 complex subunit	contributes to	Mst2 histone acetyltransferase complex	`GO:0036410` GO:0036410 defines Ptf1 as a fission-yeast Mst2-complex constituent. `DOI:10.1101/gad.1993611` Reddy et al. 2011 identified Ptf1 as an Mst2-complex component.
Eaf6 Mst2 complex subunit	contributes to	Mst2 histone acetyltransferase complex	`GO:0036410` GO:0036410 defines Eaf6 as a fission-yeast Mst2-complex constituent. `DOI:10.1101/gad.1993611` Reddy et al. 2011 identified Eaf6 as an Mst2-complex component.
Mst2 histone acetyltransferase complex	supports	histone H3K14 acetyltransferase activity	`GO:0036410` GO:0036410 defines Mst2 as an H3K14 acetyltransferase complex. `GO:0036408` GO:0036408 is the molecular-function term for histone H3K14 acetyltransferase activity. `DOI:10.1101/gad.1993611` Reddy et al. 2011 connected the Mst2 complex with H3K14 acetylation.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral family groundings for the fission-yeast Mst2 complex constituents. GO:0036410 defines five fission-yeast proteins as Mst2 histone acetyltransferase complex constituents. Exact source-neutral InterPro, Pfam, NCBIfam or UniProt family boundaries for these Mst2-complex subunit classes need narrower curation before these component labels can be grounded.

Evidence

GO:0036410 Gene Ontology cellular-component term for the Mst2 histone acetyltransferase complex.
GO:0036409 Gene Ontology cellular-component parent term for H3-K14-specific histone acetyltransferase complexes.
GO:0036408 Gene Ontology molecular-function term for histone H3K14 acetyltransferase activity.
PMID:21289066 PubMed identifier for Reddy et al. 2011, the Mst2 complex paper cited by GO:0036410.
DOI:10.1101/gad.1993611 DOI for Reddy et al. 2011, 'Elimination of a specific histone H3K14 acetyltransferase complex bypasses the RNAi pathway to regulate pericentric heterochromatin functions', verified through NCBI E-utilities.

Curation history

2026-09-27T06:20:20Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-27T06:22:16Z codex · EXPANDED_RECORD — Added H3K14 HAT parentage, three Mst2 complex exact synonyms, five fission-yeast constituent rows, fission-yeast scope, histone H3K14 acetyltransferase activity, GO/PubMed/DOI evidence, a nonmechanistic function graph, and an Mst2 complex subunit-grounding TODO.

Source: data/structures/other/mst2_histone_acetyltransferase_complex.yaml